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FLASH GENE

Symbol

MTMR3

contributors: npt/ - updated : 28-03-2006

HGNC name	myotubularin related protein 3
HGNC id	7451

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 20 - 8924 isoform 1 130.4 1170 - Zhao (2000) variant 2 19 - 8897 isoform 2 129.3 1161 - Zhao (2000) variant 3 20 - 9008 isoform 3 133.5 1198 - Zhao (2000)

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive liver         Endocrine pancreas         Nervous brain

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Muscular striatum cardiac     Muscular striatum skeletal     Nervous central

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	region similar to the active site of tyrosine phosphatases
	a double-helical motif similar to the SET interaction domain
	a FYVE domain at C-terminus

HOMOLOGY

interspecies

homolog to C.elegans y60a3a.16

intraspecies

homolog to myotubularin protein 3

Homologene

FAMILY	protein-tyrosine phosphatase family
	non-receptor class myotubularin subfamily

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm

basic FUNCTION	protein tyrosine/serine/threonine phosphatase
	putatively involved in signal transduction

CELLULAR PROCESS

protein, post translation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

phosphatidylinositol (3)-phosphate

cell & other

REGULATION

inhibited by

sodium vanadate and pervanadate,ph dependency

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS