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FLASH GENE
Symbol GRM6 contributors: mct - updated : 09-03-2016
HGNC name glutamate receptor, metabotropic 6
HGNC id 4598
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor
  • a signal peptide of 24 AA
  • a ligand-binding domain, poorly characterized cysteine-rich domains, in addition to the intracellular domains, having a pivotal role in correct trafficking of metabotropic glutamate receptors to the cell surface
    • HOMOLOGY
    interspecies homolog to C.elegans Y4C6A.2
    Homologene
    FAMILY G protein coupled receptor superfamily
    CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text photoreception
    basic FUNCTION
  • metabotropic glutamate receptor, groupe III, linked to the inhibition of cAMP cascade
  • neurotransmitter receptor present only in the synapses of the ON bipolar cell dendrites, and mediating synaptic transmission from rod and cone photoreceptors to this type of second-order neuron
  • in retinal ON bipolar cells, Go couples the metabotropic receptor GRM6 to the TRPM1 channel and closes it in the dark, thus hyperpolarizing the cell
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • FRMPD2-LRIT1-GRM6 axis regulates selective synapse formation in cone photoreceptors and is essential for normal visual function
    • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RGS7 and RGS11 are the key GTPase accelerating proteins (GAPs) in the GRM6 pathway of retinal rod ON bipolar cells that set the sensitivity and time course of light-evoked responses
  • GNB3 participates in the G-protein heterotrimer that couples GRM6 to TRPM1
  • GPR179 along with RGS7 and RGS11 controls the ability of the GRM6 cascade to gate TRPM1
  • LRIT1 interacts with FRMPD2, a photoreceptor scaffold protein, and with GRM6, an ON-bipolar cell-specific glutamate receptor
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CSNB1B
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS