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FLASH GENE
Symbol GRM6 contributors: mct - updated : 09-03-2016
HGNC name glutamate receptor, metabotropic 6
HGNC id 4598
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Visualeyeretina   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsensoryvisual  
cells
SystemCellPubmedSpeciesStageRna symbol
Visualbipolar cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor
  • a signal peptide of 24 AA
  • a ligand-binding domain, poorly characterized cysteine-rich domains, in addition to the intracellular domains, having a pivotal role in correct trafficking of metabotropic glutamate receptors to the cell surface
  • HOMOLOGY
    interspecies homolog to C.elegans Y4C6A.2
    Homologene
    FAMILY G protein coupled receptor superfamily
    CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text photoreception
    basic FUNCTION
  • metabotropic glutamate receptor, groupe III, linked to the inhibition of cAMP cascade
  • neurotransmitter receptor present only in the synapses of the ON bipolar cell dendrites, and mediating synaptic transmission from rod and cone photoreceptors to this type of second-order neuron
  • in retinal ON bipolar cells, Go couples the metabotropic receptor GRM6 to the TRPM1 channel and closes it in the dark, thus hyperpolarizing the cell
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • FRMPD2-LRIT1-GRM6 axis regulates selective synapse formation in cone photoreceptors and is essential for normal visual function
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RGS7 and RGS11 are the key GTPase accelerating proteins (GAPs) in the GRM6 pathway of retinal rod ON bipolar cells that set the sensitivity and time course of light-evoked responses
  • GNB3 participates in the G-protein heterotrimer that couples GRM6 to TRPM1
  • GPR179 along with RGS7 and RGS11 controls the ability of the GRM6 cascade to gate TRPM1
  • LRIT1 interacts with FRMPD2, a photoreceptor scaffold protein, and with GRM6, an ON-bipolar cell-specific glutamate receptor
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CSNB1B
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS