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FLASH GENE
Symbol LLGL2 contributors: mct/npt - updated : 25-02-2008
HGNC name lethal giant larvae homolog 2 (Drosophila)
HGNC id 6629
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to Drosophila DLG1(lethal giant larvae 1)
homolog to C.elegans C52A11.4
Homologene
FAMILY
  • WD repeat L(2)GL family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • playing an essential role in control of cell proliferation and differentiation during development
    • CELLULAR PROCESS cell life, proliferation/growth
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with ZEB1 (suppresses the expression of cell polarity factors, in particular of LLGL2, which we found reduced in colorectal and breast cancers) (Spaderna 2008)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to ischemic stroke
    Variant & Polymorphism SNP rs1671021 (T-->C, Phe479Leu) were significantly associated with ischemic stroke (Hamada 2010)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS