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FLASH GENE
Symbol LLGL2 contributors: mct/npt - updated : 25-02-2008
HGNC name lethal giant larvae homolog 2 (Drosophila)
HGNC id 6629
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
25 - 3547 - 1015 - Spaderna (2008)
10 - 1440 - 356 - Spaderna (2008)
26 - 3590 - 1020 - Spaderna (2008)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
Digestiveintestinelarge intestinecolon highly
 stomach   highly
Endocrinepancreas   highly
Reproductiveovary    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Digestiveepithelial cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to Drosophila DLG1(lethal giant larvae 1)
homolog to C.elegans C52A11.4
Homologene
FAMILY
  • WD repeat L(2)GL family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • playing an essential role in control of cell proliferation and differentiation during development
  • CELLULAR PROCESS cell life, proliferation/growth
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with ZEB1 (suppresses the expression of cell polarity factors, in particular of LLGL2, which we found reduced in colorectal and breast cancers) (Spaderna 2008)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to ischemic stroke
    Variant & Polymorphism SNP rs1671021 (T-->C, Phe479Leu) were significantly associated with ischemic stroke (Hamada 2010)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS