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FLASH GENE

Symbol

DAP3

contributors: mct - updated : 11-03-2025

HGNC name	death associated protein 3
HGNC id	2673

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal targeting sequence to mitochondria with a putative cleavage site
	potential P-loop nucleotide binding site
	proline rich domain
	a potential nuclear receptor-interacting domain (NR box)
	a CAYL, cysteine alanine tyrosine leucine (final four residues at the DAP3 C terminus)

HOMOLOGY

interspecies

homolog to murine Dap3

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,inner
	intracellular,cytoplasm,organelle,mitochondria,matrix
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,cytosolic,ribosome
	intracellular,nucleus,nucleoplasm
text	pro-apoptotic protein located in the small subunit of the ribosome (Miller 2008)
	detected in the cytosol and mitochondria fraction, but only a little in the nucleus fraction in the cells before anti-CD3 antibody stimulation (Tosa 2010)
	specifically localizes in the mitochondrial matrix

basic FUNCTION	involved in mediating interferon-gamma induced cell death
	potential regulatory function of mitochondrial DAP3 involved in cellular senescence (Murata 2006)
	GTP-binding constituent of the small subunit of the mitochondrial ribosome with a pro-apoptotic function (Jacques 2009)
	mitochondrial ribosomal small subunit protein, which is a novel phosphorylated target (Miller 2008)
	may participate in mitochondrial maintenance and play a role in the balance between mitochondrial homoeostasis and tumourigenesis (Jacques 2009)
	responsible for regulating apoptosis induced by various stimuli (Harada 2010)
	critical for anoikis induction (detachment of adherent epithelial cells from the extracellular matrix inducing apoptosis) (Li 2009)
	critical for TCR-mediated induction of apoptosis at the downstream of NNR4A1 (Tosa 2010)
	DAP3 plays likely important roles in mitochondrial function and dynamics
	coordinates splicing regulatory networks, not only via mediating the formation of ribonucleoprotein complexes to induce substrate-specific splicing changes, but also via modulating splicing of numerous splicing factors to cause indirect effect on splicing
	can influence mitochondrial fission by modulating dynamin-related protein phosphorylation

CELLULAR PROCESS	cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

component of mitochondrial ribosome

INTERACTION

DNA

RNA

small molecule

protein	may be interacting with MRPS27
	interacting with the glycocorticoid receptor and enhancing its ligand-induced activiry
	DAP3-binding protein termed death ligand signal enhancer (Harada 2010)
	interferon-beta promoter stimulator 1 (MAVS) binds DAP3 and induces anoikis by caspase activation (Li 2009)
	functionally associated with NR4A1 on TCR-mediated apoptosis (Tosa 2010)
	DAP3 mainly interacts with the deaminase domain of ADARB1 and represses editing via disrupting association of ADARB1 with its target transcripts

cell & other

REGULATION

Other

phosphorylated in an Akt-dependent manner, correlating with the suppression of DAP3-facilitated apoptosis in anoikis (Tosa 2010)

ASSOCIATED DISORDERS

corresponding disease(s)

PRLTS7

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in pancreatic tumour tissues and was significantly associated with shorter survival tumoral     --low   significantly associated with local recurrence, distant metastasis and mortality

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	can provide a reference for hepatocellular carcinoma (HCC) diagnosis, treatment and prognosis assessment
Therapy target

ANIMAL & CELL MODELS