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FLASH GENE
Symbol APBA2 contributors: mct - updated : 27-02-2008
HGNC name amyloid beta (A4) precursor protein-binding, family A, member 2 (X11-like)
HGNC id 579
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N termnial domain binding Munc18.1
  • a phosphotyrosine domain (PID) interacting with the NPXY motif of APP
  • two PDZ domains at the C terminus
    • HOMOLOGY
    interspecies homolog to murine Apba2
    intraspecies homolog to APBA1 ( highly homologous in the C-terminal region )
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • putative function in synaptic exocytosis
  • may be important in the physiology of APP family proteins as well as in the regulation of Abeta production
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein can bind to the conserved YENPTY motif in the APP C terminus
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to schizophrenia
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS