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FLASH GENE
Symbol APBA2 contributors: mct - updated : 27-02-2008
HGNC name amyloid beta (A4) precursor protein-binding, family A, member 2 (X11-like)
HGNC id 579
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 3627 - 749 - Xie (2005)
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen    
Nervousbrain    
 nerve    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N termnial domain binding Munc18.1
  • a phosphotyrosine domain (PID) interacting with the NPXY motif of APP
  • two PDZ domains at the C terminus
  • HOMOLOGY
    interspecies homolog to murine Apba2
    intraspecies homolog to APBA1 ( highly homologous in the C-terminal region )
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • putative function in synaptic exocytosis
  • may be important in the physiology of APP family proteins as well as in the regulation of Abeta production
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein can bind to the conserved YENPTY motif in the APP C terminus
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to schizophrenia
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS