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FLASH GENE
Symbol DUSP6 contributors: mct - updated : 27-10-2011
HGNC name dual specificity phosphatase 6
HGNC id 3072
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two N terminal CH2 domains
  • an extended active site sequence motif conserved in dual specificity phosphatases
  • a rhodanese domain
  • a tyrosine-protein phosphatase domain
    • HOMOLOGY
    Homologene
    FAMILY dual specificity protein phosphatase subfamily
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • inactivating map kinases and having a specificity for the ERK family
  • having a function in shuttles between the nucleus and cytoplasm
  • important regulator of PDGF-induced Erk phosphorylation acting in both a rapid positive feed-forward and a later negative feed-back loop
  • growth suppressor whose inactivation could promote the progression of lung cancer
  • DUSP5 and DUSP6 selectively control ERK pathway activity and proliferation
  • protective role of the MAPK signaling in oligodendrocyte death and DUSP6 is relevant negative regulator of this survival pathway
  • role of DUSP6 in neuronal cell death
  • dephosphorylates phosphotyrosine and phosphothreonine residues on extracellular signal-regulated kinase (ERK1/2; MAPK1/2) to inactivate the ERK1/2 kinase
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein inactivating ERK2
    cell & other
    REGULATION
    Other regulated by ETS2 (ETS2 is a key regulatory factor in the transcriptional control of DUSP6 (Dusp6) in responding to activity of MAPK1) (Furukawa (2008)
    PEDRE controls pluripotent state-specific expression of DUSP6 (Zhang, 2009)
    post-transcriptional regulation is a key process in the control of DUSP6 expression
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in primary pancreatic cancer
    tumoral     --over  
    exerts a tumor-promoting role in human glioblastomas exacerbating the malignant phenotype
    constitutional     --over  
    in optic nerves from multiple sclerosis patients before the appearance of evident damage in this structure
    Susceptibility to congenital Hypogonadotropic Hypogonadism
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyautoimmunemultiple sclerosis
    targeting Dusp6 may be a useful strategy to prevent oligodendrocyte death in multiple sclerosis and other diseases involving CNS white matter.
    ANIMAL & CELL MODELS