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FLASH GENE
Symbol CASP10 contributors: mct - updated : 18-04-2011
HGNC name caspase 10, apoptosis-related cysteine protease
HGNC id 1500
Corresponding disease
ALPS2 autoimmune inherited lymphoproliferative syndrome, type II
Location 2q33.1      Physical location : 202.047.620 - 202.094.110
Synonym name
  • FADD homologous-like protease
  • apoptotic protease Mch-4
  • ICE-like apoptotic protease 4
  • FAS-associated death domain protein interleukin-1B-converting enzyme
  • 2
    Synonym symbol(s) MCH4, FLICE2, ALPS2
    EC.number 3.4.22.36
    DNA
    TYPE functioning gene
    STRUCTURE 38.77 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC389069 2 similar to selenophosphate synthetase 1 LOC389070 2 LOC389070 FLJ38973 2q33.1 hypothetical protein FLJ38973 FLJ37953 2q33.1 hypothetical protein FLJ37953 FLJ22555 2q33.1 hypothetical protein FLJ22555 DNAPTP6 2q33.2 DNA polymerase-transactivated protein 6 FLJ37818 2q33.2 hypothetical protein FLJ37818 FLJ31322 2q33.2 hypothetical protein FLJ31322 TRIPIN 2q33.2 tripin AOX1 2q33 aldehyde oxidase 1 AOX2 2q33.2 aldehyde oxidase 2 BZW1 2q33 basic leucine zipper and W2 domains 1 LOC391472 2 similar to bA476B13.3 (KIAA0699 protein) CLK1 2q33 CDC-like kinase 1 PPIL3 2q33 peptidylprolyl isomerase (cyclophilin)-like 3 NIF3L1 2q33-q34 NIF3 NGG1 interacting factor 3-like 1 (S. pombe) ORC2L 2q33 origin recognition complex, subunit 2-like (yeast) MGC39518 2q33.2 hypothetical protein MGC39518 NDUFB3 2q31.3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa CFLAR 2q33 CASP8 and FADD-like apoptosis regulator CASP10 2q33-q34 caspase 10, apoptosis-related cysteine protease CASP8 2q33-q34 caspase 8, apoptosis-related cysteine protease ALS2CR12 2q33.2 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 12 ALS2CR3 2q33 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 3 ALS2CR2 2q33-q34 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2 FLJ25351 2q33.2 hypothetical protein FLJ25351 ALS2CR4 2q33 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 4 MPP4 2q33.2 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) ALS2 2q33.2 amyotrophic lateral sclerosis 2 (juvenile) LOC151256 2q33.2 hypothetical LOC151256 ALS2CR7 2q33.2 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 7 FZD7 2q33 frizzled homolog 7 (Drosophila) FLJ39061 2q33.2 hypothetical protein FLJ39061 LOC339809 2q33.2 KIAA2012 protein UBL1 2q32.3-q33 ubiquitin-like 1 (sentrin) NOP5/NOP58 2q33.2 ubiquitin-like 1 (sentrin) BMPR2 2q33-q34 bone morphogenetic protein receptor, type II (serine/threonine kinase) FLJ38771
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 splicing 2288 58.9 521 - 2011 21368896
  • lacking exon 10 distinct C terminus
  • CASP10B
  • had no effect or were weakly anti-apoptotic
  • its unique C-terminal end was responsible for its degradation by the ubiquitin-proteasome pathway and for its lack of pro-apoptotic activity compared with caspase-10A and -10D
  • 8 splicing 5777 54.6 479 - 2011 21368896
  • lacking exons 6, 7 and 43 internal AA
  • CASP10A
  • strongly increased TRAIL and FasL sensitivity
  • 10 splicing 5906 59 522 - 2011 21368896
  • full lenght
  • CASP10D
  • strongly increased TRAIL and FasL sensitivity
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
    Nervousbrain    
    Reproductivemale systemprostate   
     male systemtestis   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines chronic myelogenous leukemia cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text lung
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two N terminal FADD-like DEATH effector domains
  • a conserved QACXG pentapeptide active site motif
  • mono polymer heteromer , dimer
    isoforms Precursor
    HOMOLOGY
    interspecies homolog to C.elegans Ced-3
    Homologene
    FAMILY peptidase C14 family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    text stored in the mitochondrial intermembrane space and released into cytosol after appropriate apoptotic stimuli
    basic FUNCTION
  • recruited to the CD99 and p55 tumor necrosis factor receptor signaling complexes and promoting CD95 (APO1/Fas) apoptosis
  • CASP8 and CASP10 may be involved in the pathogenesis of rectal cancer
  • involved in the extrinsic death receptor pathway
  • prodeath role for both cleaved and uncleaved CASP10
  • may play a critical role in PTK7-knockdown-induced apoptosis, downstream of mitochondria
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text
  • can serve as an initiator caspase in Fas signaling leading to Bid processing, caspase cascade activation, and apoptosis
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • activating CASP3 and CASP7
  • ABCF1, AKAP1, CPE, DOPEY1 and GOPC may be targeted specifically by the initiator CASP8 and CASP10 during the early stages of apoptosis
  • RIOK3 interacted with caspase-10 (interaction was mediated by the RIO domain of RIOK3 and each death effector domain of CASP10)
  • cell & other
    REGULATION
    activated by CASP9
    CASP8 which cleaved caspase-10 directly
    ASSOCIATED DISORDERS
    corresponding disease(s) ALPS2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in term placentas from women with pregnancies complicated by preeclampsia
    tumoral somatic mutation      
    CASP10 mutation might contribute to the pathogenesis of some colon carcinomas together with other CASP gene mutations (CASP3, CASP7, CASP8)
    tumoral somatic mutation      
    CASP10 mutation might contribute to the pathogenesis of factions of T-ALL and multiple myelomas
    Susceptibility
  • to breast cancer
  • Variant & Polymorphism other polymorphisms significantly associated with a highly decreased familial breast cancer risk
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS