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FLASH GENE
Symbol IGLL1 contributors: np - updated : 15-09-2006
HGNC name immunoglobulin lambda-like polypeptide 1
HGNC id 5870
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an immunoglobulin C-2 type domain
    • HOMOLOGY
    interspecies ortholog to murine Igl-5
    homolog to C.elegans D2007.2
    Homologene
    FAMILY
  • immunoglobulin gene superfamily
    • CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • required for rearrangement of the Ig kappa light chain gene in pro-B cell lines
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
  • associates non-covalently with VPREB1
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • encoding a gene associating with VpreB gene product
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) AGM2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    in B cell deficiency and agammaglobulinemia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS