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FLASH GENE
Symbol IGLL1 contributors: np - updated : 15-09-2006
HGNC name immunoglobulin lambda-like polypeptide 1
HGNC id 5870
Corresponding disease
AGM2 agammaglobulinemia 2
Location 22q11.23      Physical location : 23.915.314 - 23.922.495
Synonym name
  • CD179b antigen
  • pre-B lymphocyte-specific protein-2
  • immunoglobulin omega polypeptide chain
  • Ig lambda-5
  • CD179 antigen-like family member B
  • immunoglobulin-related 14.1 protein
  • Synonym symbol(s) IGO, 14.1, IGL1, IGL5, IGLL, IGVPB, CD179b, lambda5, CD179B, VPREB2
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text clustered in IGLL@
    STRUCTURE 7.18 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    Map see IGLL@
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 splicing 901 19.13 213 - Hollis, Fautsch (2006)
    2 splicing 785 - 84 - Hollis, Fautsch (2006)
    lacking an alternate exon which causes a frameshift
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticthymus   highly
    Cardiovascularheart    
    Lymphoid/Immunelymph node    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Lymphoid    
    cell lineage preB-cell specific
    cell lines a special B-cell line which is surface Ig negative
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an immunoglobulin C-2 type domain
  • HOMOLOGY
    interspecies ortholog to murine Igl-5
    homolog to C.elegans D2007.2
    Homologene
    FAMILY
  • immunoglobulin gene superfamily
  • CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • required for rearrangement of the Ig kappa light chain gene in pro-B cell lines
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
  • associates non-covalently with VPREB1
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • encoding a gene associating with VpreB gene product
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) AGM2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    in B cell deficiency and agammaglobulinemia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS