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FLASH GENE

Symbol

IGLL1

contributors: np - updated : 15-09-2006

HGNC name	immunoglobulin lambda-like polypeptide 1
HGNC id	5870

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	AGM2 agammaglobulinemia 2
Location	22q11.23      Physical location : 23.915.314 - 23.922.495
Synonym name	CD179b antigen
	pre-B lymphocyte-specific protein-2
	immunoglobulin omega polypeptide chain
	Ig lambda-5
	CD179 antigen-like family member B
	immunoglobulin-related 14.1 protein
Synonym symbol(s)	IGO, 14.1, IGL1, IGL5, IGLL, IGVPB, CD179b, lambda5, CD179B, VPREB2

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
text	clustered in IGLL@
STRUCTURE	7.18 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

confirmed

Map

see IGLL@

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_020070 3 splicing 901 NP_064455 19.13 213 - Hollis, Fautsch (2006) NM_152855 2 splicing 785 NP_690594 - 84 - Hollis, Fautsch (2006) lacking an alternate exon which causes a frameshift

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic thymus       highly Cardiovascular heart         Lymphoid/Immune lymph node         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Lymphoid

cell lineage	preB-cell specific
cell lines	a special B-cell line which is surface Ig negative
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

an immunoglobulin C-2 type domain

HOMOLOGY

interspecies	ortholog to murine Igl-5
	homolog to C.elegans D2007.2

Homologene

FAMILY

immunoglobulin gene superfamily

CATEGORY

immunity/defense

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane

basic FUNCTION

required for rearrangement of the Ig kappa light chain gene in pro-B cell lines

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense

PATHWAY

metabolism

signaling

a component

associates non-covalently with VPREB1

INTERACTION

DNA

RNA

small molecule

protein

encoding a gene associating with VpreB gene product

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

AGM2

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation       in B cell deficiency and agammaglobulinemia

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS