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FLASH GENE

Symbol

CCL19

contributors: mct/npt - updated : 21-02-2012

HGNC name	chemokine (C-C motif) ligand 19
HGNC id	10617

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	9p13      Physical location : 34.689.568 - 34.691.274
Synonym name	exodus 3
	macrophage inflammatory protein 3 beta
	EBT1 ligand chemokine
	small inducible cytokine subfamily A (Cys-Cys), member 19
	CK beta-11
Synonym symbol(s)	ELC, CKb11, MIP3B, MIP-3b, SCYA19, MGC34433

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	1.71 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence

Binding site

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006274 4 - 684 11 98 - 2008 18047937

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive pharynx       highly   stomach       lowly Lymphoid/Immune lymph node           spleen       highly Respiratory lung       lowly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Lymphoid

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	fetal lung

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

putative signal sequence

isoforms

Precursor

HOMOLOGY

interspecies

homolog to murine Scya19

Homologene

FAMILY

small inducible cytokine, chemokine beta, CC subfamily

CATEGORY

signaling cytokine , receptor membrane

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	key factor enabling all these early T cell responses, including the occurrence of calcium transients
	promotes Ag-independent responses and increases the probability of cognate MHC-peptide encounter
	macrophages participate in lymphangiogenesis in idiopathic diffuse alveolar damage through CCL19-CCR7 signal
	CCL19/21 induced PI3K-dependent phosphorylation of Akt/protein kinase B, activation of the Rho/Rho-associated coiled-coil forming protein kinases/myosin light chain pathway and MAPKs phosphorylation
	CCL21 together with another CCR7 ligand, CCL19, direct the navigation and compartmentation of T cells within secondary lymphoid tissues
	controls signaling events in T cells

CELLULAR PROCESS

cell migration & motility

PHYSIOLOGICAL PROCESS

immunity/defense

text	immune response

PATHWAY

metabolism

signaling

signal transduction

a component

part of CCL19, CCL21/CCR7 chemokine system expressed in inflamed muscles of polymyositis and may be involved in the pathomechanism of polymyositis

INTERACTION

DNA

RNA

small molecule

protein	ligand for the orphan receptor EBI1 (CMKBR7)
	ligand of CCR7
	specific ligand for CCRL2 (CCL19 is known to be critically involved in lymphocyte and dendritic cell trafficking, and CCL19-binding competition by CCRL2 might be involved in modulating these processes)
	FHL2 is a novel regulator of CCL19-induced dendritic cell (DC) migration
	CCL19 stimulation of na
	ve T cells regulates expression of MAPK7, KLF2, and S1PR1
	CCL19 controls T cell regulation of S1PR1 expression
	after binding to CCL19, CCR7 signaling leads to increased expression and phosphorylation of MAPK7 and up-regulation of KLF2, which results in S1PR1 expression and a migration of T lymphocytes

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS