basic FUNCTION
| NOTCH1 ligand playing a pivotal role in the development of the organ of Corti and specification of some vestibular sensory epithelia |
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functioning as WNT-dependent Notch signaling activator, and key molecule maintaining the homeostasis of stem and progenitor cells |
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JAG1 expression decreased hair cells, JAG1 suppression increased hair cells |
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undergoing a metalloprotease-dependent cleavage resulting in the shedding of its extracellular domain and this domain seems able to fulfill a biological function, probably by antagonizing Notch signaling |
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playing an essential role for vascular remodeling, and its primary role is to potentiate the development of neighboring vascular smooth muscle |
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involved in endothelial-pericyte interactions |
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DLL4 and Jagged1 have opposing effects on angiogenesis |
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unique role for JAG1 in preventing the induction of T-lineage differentiation in hematopoietic stem cells |
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crucial role for JAG1 in valve morphogenesis |
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in addition to its role in early heart development, JAG1 signaling is required postnatally to prevent valve calcification |
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crucial role for JAG1 in the endocardium during heart development |
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JAG1-regulated angiogenesis |
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JAG1-mediated NOTCH1 signaling regulates multiple cell fate decisions as well as differentiation in the respiratory system to coordinate lung development and to maintain a balance of airway cell types in adult life |
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is necessary for postnatal and adult neurogenesis in the dentate gyrus |
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JAG1 intracellular domain-mediated inhibition of NOTCH1 signalling regulates cardiac homeostasis in the postnatal heart |
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JAG1 signaling within the osteoblast lineage regulates bone metabolism in a compartment-dependent manner |
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critical role of osteolineage JAG1 in bone homeostasis, where JAG1 maintains the transition of osteoprogenitor (OP) to maturing osteoblasts |
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DLL4 and JAG1 promote tumour growth by modulating tumour angiogenesis via different mechanisms |
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JAG1/NOTCH3 signaling pathway plays a key role in angiogenesis of breast cancer |
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both NOTCH1 and its ligands DLL1 and JAG1 in B cells promote antibody production |
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membrane expression of JAG1 is necessary but not sufficient for JAG1 function |