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FLASH GENE
Symbol PPEF1 contributors: mct - updated : 16-04-2019
HGNC name protein phosphatase, EF hand calcium-binding domain 1
HGNC id 9243
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • protein phosphatase with helix- loop- helix
  • EF calcium binding domains
  • one IQ domain
    • HOMOLOGY
    interspecies homolog to Drosophila retinal degeneration C (rdgc)
    homolog to murine Ppef1
    Homologene
    FAMILY PPP phosphatase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • serine-threonine phosphatase activity
  • playing a role in specific sensory neuron function and/or development
  • PPEF1 plays a pivotal role in tumorigenesis of lung cancer cells by reducing PDCD5-mediated genotoxic stress responses
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Mg2+
  • Mn2+
    • protein
  • PPEF1 interacts with and dephosphorylates PDCD5 at Ser-119, which leads to PDCD5 destabilization
  • PPEF1 suppressed TP53-mediated genotoxic stress response via negative regulation of PDCD5
    • cell & other
    REGULATION
    Phosphorylated by CSNK2A1 at Ser119, which is required for nuclear translocation in response to genotoxic stress
    Other regulated by calcium
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS