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FLASH GENE
Symbol PPEF1 contributors: mct - updated : 16-04-2019
HGNC name protein phosphatase, EF hand calcium-binding domain 1
HGNC id 9243
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Reproductivefemale systemuteruscervix  
 male systemtestis   
cell lineage sensory neurons of neural crest origin
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • protein phosphatase with helix- loop- helix
  • EF calcium binding domains
  • one IQ domain
  • HOMOLOGY
    interspecies homolog to Drosophila retinal degeneration C (rdgc)
    homolog to murine Ppef1
    Homologene
    FAMILY PPP phosphatase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • serine-threonine phosphatase activity
  • playing a role in specific sensory neuron function and/or development
  • PPEF1 plays a pivotal role in tumorigenesis of lung cancer cells by reducing PDCD5-mediated genotoxic stress responses
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Mg2+
  • Mn2+
  • protein
  • PPEF1 interacts with and dephosphorylates PDCD5 at Ser-119, which leads to PDCD5 destabilization
  • PPEF1 suppressed TP53-mediated genotoxic stress response via negative regulation of PDCD5
  • cell & other
    REGULATION
    Phosphorylated by CSNK2A1 at Ser119, which is required for nuclear translocation in response to genotoxic stress
    Other regulated by calcium
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS