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FLASH GENE

Symbol

BTN2A1

contributors: mct - updated : 16-06-2008

HGNC name	butyrophilin, subfamily 2, member A1
HGNC id	1136

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 8 - 2906 - 527 - Ruddy, Malcherek (2007) variant 2 8 splicing 3129 - 334 - Ruddy, Malcherek (2007)

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune thymus       highly Nervous nerve       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a chicken B group B-G Ig-like domain (IgV-IgC1)
	a transmembrane segment a large B30-2
	C terminal domain
	a signal sequence,and two short exons (7 and 9 AA)

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY	butyrophilin subfamily 2
	B box family of proteins

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION

involved in cell proliferation and development

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

lipid/lipoprotein

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

ligand for CD209 (tumor- or tissue-specific glycosylation of BTN2A1 governing recognition by CD209 on immature monocyte-derived dendritic cells)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS