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FLASH GENE
Symbol PEG3 contributors: mct/pgu - updated : 18-03-2010
HGNC name paternally expressed 3
HGNC id 8826
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 12 C2H2-type zinc fingers
  • two novel proline-rich motifs
  • leucine-rich repeats
    • mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • Krüppel C2H2-type zinc finger protein family
    • CATEGORY transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • contributing to glioma carcinogenesis
  • involved in the TP53-mediated cell death pathway as a downstream effector of TP53 in brain ischemia/hypoxia
  • inhibits Wnt signaling and regulates glioma growth
  • inducing apoptosis in ccoperation with SIAH1A
  • acting as a mediator between TP53 and BAX in a neuronal death pathway that is activated by DNA damage
  • acting synergistically with TRAF2 and inhibits TNF-induced apoptosis through activation of NF-KappaB
  • possesses a tumor suppressor activity in glioma cells
  • serves as an invaluable marker for competent self-renewing stem cells in a wide array of adult tissues
  • PEG3/reporter activity identifies stem/progenitor cells of the adult CNS and can be used to track a self-renewing population
    • CELLULAR PROCESS cell life, cell death/apoptosis
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SIAH1A and SIAH2
  • interacting with TRAF2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in glioma (by aberrant DNA methylation of an exonic CpG island)
    Susceptibility for cancer as well as neurobehavioral deficits
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS