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FLASH GENE
Symbol HAS1 contributors: mct/npt - updated : 28-04-2015
HGNC name hyaluronan synthase 1
HGNC id 4818
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
increase in serum hyaluronan in endometrial cancer may be associated with disease progression through myometrial invasion and lymph-vascular space involvement
tumoral     --other  
aberrant HAS1 splicing in multiple myeloma, bladder cancer and Waldenstrom macroglobulinemia (Ghosh (2009)
tumoral     --over  
in colon, ovarian, endometrial, mesothelioma and bladder cancers (Ghosh 2009)
constitutional       gain of function
during muscle hypertrophy
constitutional       gain of function
in states associated with inflammation, like atherosclerosis, osteoarthritis, and infectious lung disease
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS