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FLASH GENE

Symbol

MAPK12

contributors: - updated : 13-01-2007

HGNC name	mitogen-activated protein kinase 12
HGNC id	6874

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	KIM domains
	a protein kinase domain
	three PDZ domain-containing binding partners, LIN7C, SCRIB, and outer membrane protein 25 (OMP25)
	C-terminal 5 amino acids directing interaction with the PDZ domain-containing substrates SNTA1 and SAP90/PSD95

mono polymer

monomer

HOMOLOGY

Homologene

FAMILY

mitogen-activated protein kinase (MAPK) family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria

basic FUNCTION	phosphorylating enzyme for ELK1, ATF2 and others
	functioning as a signal transducer during differentiation of myoblasts to myotubes
	may inhibit cell proliferation while promoting differentiation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

phosphotyrosine mediated pathway

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	binds 2 magnesium ions

protein	interacts with the PDZ domain of the syntrophin SNTA1
	interacts with SH3BP5

cell & other

REGULATION

activated by	MAP2K3,MAP2K6
	CD14 and LBP
	phosphorylation on threonine and tyrosine

induced by

proinflammatory cytokines,environmental stress

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   in myoblast that exhibit an attenuated fusion capacity

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS