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FLASH GENE

Symbol

FCAR

contributors: mct - updated : 23-09-2014

HGNC name	Fc fragment of IgA, receptor for
HGNC id	3608

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol   bone marrow     highly Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic granulocyte Homo sapiens Blood/Hematopoietic monocyte Homo sapiens Lymphoid/Immune macrophage Homo sapiens

cell lineage
cell lines
fluid/secretion	blood

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two Ig extracellular domains
	a short cytoplasmic tail without the tyrosine-based inhibitory motif (ITIM)
	a transmembrane (TM) and intracellular domain

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY

natural killer inhibitory receptor family

CATEGORY

antigen , receptor

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane

basic FUNCTION	Fc receptor expressed on granulocyte, monocyte, macrophage, T cell, B cel
	functions as an FCER1G ITAM-dependent apoptotic module that may be fundamental for controlling inflammation and tumor growth
	is pivotal for the inflammatory responses against IgA-opsonized pathogens
	is essential for IgA-mediated immune responses
	its endocytosis is clathrin- and dynamin-dependent, but is not regulated by RAB5, and the endocytic motif is not located in the cytoplasmic domain of FCAR
	involved in IgA complex formation and may affect the development of IgA nephropathy (IgAN)
	mediating several functions including cytokine production
	the most potent FcR on neutrophils for induction of Ab-mediated tumor cell killing
	mediates cell activation or inhibition depending on the type of ligand interaction, which can be either multivalent or monovalent

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

complexing with a cytoplasmic homodimer gamma subunit via the immunoreceptor based inhibitory motif (ITIM)

INTERACTION

DNA

RNA

small molecule

protein	binds to the fc region of immunoglobulins alpha
	PPP2CA involvement is a molecular mechanism for FCAR ligand binding regulation, a key step in initiating an immune response
	CRP induced FCAR surface expression, phagocytosis, and TNF secretion
	CEBPA interacts with the ETS domain of widely expressed GABPA, which leads to cooperative transcriptional activation of the myeloid-specific promoter for FCAR in part by facilitating recruitment of CEBPA to the promoter

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in IgA nephropathy without disease progression

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS