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FLASH GENE
Symbol FCAR contributors: mct - updated : 23-09-2014
HGNC name Fc fragment of IgA, receptor for
HGNC id 3608
DNA
TYPE functioning gene
STRUCTURE 16.38 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site
text structure
  • GABPA and CEBPA synergistically activated the FCAR promoter 280-fold
  • MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1605 - 265 phagocytic cells including macrophages, monocytes eosino and neutrophils 2003 12791088
  • CD89-U06 or V2
  • 4 splicing 1383 - 191 phagocytic cells including macrophages, monocytes eosino and neutrophils 2003 12791088
    CD89-U08 or V3
    4 splicing 1635 - 275 phagocytic cells including macrophages, monocytes eosino and neutrophils 2003 12791088
    3 splicing 1347 - 179 phagocytic cells including macrophages, monocytes eosino and neutrophils 2003 12791088
    CD89-U10 or V5
    4 splicing 1561 - 209 phagocytic cells including macrophages, monocytes eosino and neutrophils 2003 12791088
    - splicing 1267 - 227 phagocytic cells including macrophages, monocytes eosino and neutrophils 2003 12791088
    5 splicing 1671 - 287 phagocytic cells including macrophages, monocytes eosino and neutrophils 2003 12791088
  • CD89-U02 or V1 or deltaS3
  • 4 splicing 1569 - 253 phagocytic cells including macrophages, monocytes eosino and neutrophils 2003 12791088
    3 - 1344 - 178 - 2003 12791088
    4 - 1636 - 239 - 2003 12791088
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
     bone marrow  highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticgranulocyte Homo sapiens
    Blood/Hematopoieticmonocyte Homo sapiens
    Lymphoid/Immunemacrophage Homo sapiens
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two Ig extracellular domains
  • a short cytoplasmic tail without the tyrosine-based inhibitory motif (ITIM)
  • a transmembrane (TM) and intracellular domain
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY natural killer inhibitory receptor family
    CATEGORY antigen , receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • Fc receptor expressed on granulocyte, monocyte, macrophage, T cell, B cel
  • functions as an FCER1G ITAM-dependent apoptotic module that may be fundamental for controlling inflammation and tumor growth
  • is pivotal for the inflammatory responses against IgA-opsonized pathogens
  • is essential for IgA-mediated immune responses
  • its endocytosis is clathrin- and dynamin-dependent, but is not regulated by RAB5, and the endocytic motif is not located in the cytoplasmic domain of FCAR
  • involved in IgA complex formation and may affect the development of IgA nephropathy (IgAN)
  • mediating several functions including cytokine production
  • the most potent FcR on neutrophils for induction of Ab-mediated tumor cell killing
  • mediates cell activation or inhibition depending on the type of ligand interaction, which can be either multivalent or monovalent
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with a cytoplasmic homodimer gamma subunit via the immunoreceptor based inhibitory motif (ITIM)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to the fc region of immunoglobulins alpha
  • PPP2CA involvement is a molecular mechanism for FCAR ligand binding regulation, a key step in initiating an immune response
  • CRP induced FCAR surface expression, phagocytosis, and TNF secretion
  • CEBPA interacts with the ETS domain of widely expressed GABPA, which leads to cooperative transcriptional activation of the myeloid-specific promoter for FCAR in part by facilitating recruitment of CEBPA to the promoter
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in IgA nephropathy without disease progression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS