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FLASH GENE

Symbol

CASP4

contributors: shn/npt/pgu - updated : 06-04-2020

HGNC name	caspase 4, apoptosis-related cysteine peptidase
HGNC id	1505

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed immunology autoimmune   represents a novel target for the treatment of (auto)inflammatory diseases

ANIMAL & CELL MODELS

	knock-down of CASP4 by siRNA reduces NF-kappaB activation and nuclear translocation
	Casp11(-/-) mice, exhibited defects in IL-1&
	946; production and harboured a mutation in the Casp11 locus that attenuated caspase-11 expression
	loss of caspase-11 rather than caspase-1 protected mice from a lethal dose of lipopolysaccharide