Citations for
1CASP4, IRF1, IRF1
IRF1 and IRF2 regulate the non-canonical inflammasome.
Thygesen SJ, Stacey KJ.
EMBO Rep 20(9):e48891. doi: 10.15252/embr.201948891. Epub 2019 Aug 5. 2019
2CASP4, IRF2
A genome-wide screen identifies IRF2 as a key regulator of caspase-4 in human cells.
Benaoudia S, Martin A, Puig Gamez M, Gay G, Lagrange B, Cornut M, Krasnykov K, Claude JB, Bourgeois CF, Hughes S, Gillet B, Allatif O, Corbin A, Ricci R, Henry T.
EMBO Rep 20(9):e48235. doi: 10.15252/embr.201948235. Epub 2019 Jul 29. 2019
3CASP4, GBP1
Human GBP1 is a microbe-specific gatekeeper of macrophage apoptosis and pyroptosis.
Fisch D, Bando H, Clough B, Hornung V, Yamamoto M, Shenoy AR, Frickel EM.
EMBO J 38(13):e100926. doi: 10.15252/embj.2018100926. Epub 2019 Jun 3. 2019
4CASP4
CASP4 gene silencing in epithelial cancer cells leads to impairment of cell migration, cell-matrix adhesion and tissue invasion.
Papoff G, Presutti D, Lalli C, Bolasco G, Santini S, Manelfi C, Fustaino V, Alemà S, Ruberti G.
Sci Rep 8(1):17705. doi: 10.1038/s41598-018-35792-8. 2018
5CASP4
CASP4/caspase-11 promotes autophagosome formation in response to bacterial infection.
Krause K, Caution K, Badr A, Hamilton K, Saleh A, Patel K, Seveau S, Hall-Stoodley L, Hegazi R, Zhang X, Gavrilin MA, Amer AO.
Autophagy 14(11):1928-1942. doi: 10.1080/15548627.2018.1491494. Epub 2018 Aug 31. 2018
6CASP4
Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11.
Lagrange B, Benaoudia S, Wallet P, Magnotti F, Provost A, Michal F, Martin A, Di Lorenzo F, Py BF, Molinaro A, Henry T.
Nat Commun 9(1):242. doi: 10.1038/s41467-017-02682-y. 2018
7CASP1, CASP4, IL1B
Involvement of caspase-4 in IL-1 beta production and pyroptosis in human macrophages during dengue virus infection.
Cheung KT, Sze DM, Chan KH, Leung PH.
Immunobiology 223(4-5):356-364. doi: 10.1016/j.imbio.2017.10.044. Epub 2017 Oct 26. 2018
8CASP4, CTSG, IL1A
Caspase-4 activation by a bacterial surface protein is mediated by cathepsin G in human gingival fibroblasts.
Jun HK, Jung YJ, Ji S, An SJ, Choi BK.
Cell Death Differ 25(2):380-391. doi: 10.1038/cdd.2017.167. Epub 2017 Oct 27. 2018
9CASP4, CASP5, SCAF11
High-affinity caspase-4 binding to LPS presented as high molecular mass aggregates or in outer membrane vesicles.
Wacker MA, Teghanemt A, Weiss JP, Barker JH.
Innate Immun 23(4):336-344. doi: 10.1177/1753425917695446. Epub 2017 Jan 1. 2017
10CASP4, IFNA1
Interferon α Induces the Apoptosis of Cervical Cancer HeLa Cells by Activating both the Intrinsic Mitochondrial Pathway and Endoplasmic Reticulum Stress-Induced Pathway.
Shi WY, Cao C, Liu L.
Int J Mol Sci 17(11). pii: E1832. 2016
11CASP4
The human-specific CASP4 gene product contributes to Alzheimer-related synaptic and behavioural deficits.
Kajiwara Y, McKenzie A, Dorr N, Gama Sosa MA, Elder G, Schmeidler J, Dickstein DL, Bozdagi O, Zhang B, Buxbaum JD.
Hum Mol Genet 25(19):4315-4327. doi: 10.1093/hmg/ddw265. Epub 2016 Aug 11. 2016
12CASP3, CASP4
Proplatelet formation in megakaryocytes is associated with endoplasmic reticulum stress.
Morishima N, Nakanishi K.
Genes Cells 21(7):798-806. doi: 10.1111/gtc.12384. Epub 2016 Jun 14. 2016
13CASP4, CASP5, IL1A, IL1B
Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes.
Vigaṇ E, Diamond CE, Spreafico R, Balachander A, Sobota RM, Mortellaro A.
Nat Commun 6:8761. doi: 10.1038/ncomms9761. 2015
14CASP4, NLRP3
Caspase-4 mediates non-canonical activation of the NLRP3 inflammasome in human myeloid cells.
Schmid-Burgk JL, Gaidt MM, Schmidt T, Ebert TS, Bartok E, Hornung V.
Eur J Immunol 45(10):2911-7. doi: 10.1002/eji.201545523. Epub 2015 Aug 6. 2015
15CASP4
Human caspase-4 mediates noncanonical inflammasome activation against gram-negative bacterial pathogens.
Casson CN, Yu J, Reyes VM, Taschuk FO, Yadav A, Copenhaver AM, Nguyen HT, Collman RG, Shin S.
Proc Natl Acad Sci U S A 112(21):6688-93. doi: 10.1073/pnas.1421699112. Epub 2015 May 11. 2015
16CASP4, CASP5
NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5.
Baker PJ, Boucher D, Bierschenk D, Tebartz C, Whitney PG, D'Silva DB, Tanzer MC, Monteleone M, Robertson AA, Cooper MA, Alvarez-Diaz S, Herold MJ, Bedoui S, Schroder K, Masters SL.
Eur J Immunol 45(10):2918-26. doi: 10.1002/eji.201545655. Epub 2015 Aug 24. 2015
17CASP4
A critical role for human caspase-4 in endotoxin sensitivity.
Kajiwara Y, Schiff T, Voloudakis G, Gama Sosa MA, Elder G, Bozdagi O, Buxbaum JD.
J Immunol 193(1):335-43. doi: 10.4049/jimmunol.1303424. Epub 2014 May 30. 2014
18CASP4, IL1B, TLR3
TLR3 mediates release of IL-1β and cell death in keratinocytes in a caspase-4 dependent manner.
Grimstad Ø, Husebye H, Espevik T.
J Dermatol Sci 72(1):45-53. doi: 10.1016/j.jdermsci.2013.05.006. Epub 2013 Jun 12. 2013
19CASP4
Caspase-4 is required for activation of inflammasomes.
Sollberger G, Strittmatter GE, Kistowska M, French LE, Beer HD.
J Immunol 188(4):1992-2000. doi: 10.4049/jimmunol.1101620. Epub 2012 Jan 13. 2012
20CASP4
Non-canonical inflammasome activation targets caspase-11.
Kayagaki N, Warming S, Lamkanfi M, Vande Walle L, Louie S, Dong J, Newton K, Qu Y, Liu J, Heldens S, Zhang J, Lee WP, Roose-Girma M, Dixit VM.
Nature. 479(7371):117-21. 2011
21CASP4, CASP9
Caspase-4 directly activates caspase-9 in endoplasmic reticulum stress-induced apoptosis in SH-SY5Y cells.
Yamamuro A, Kishino T, Ohshima Y, Yoshioka Y, Kimura T, Kasai A, Maeda S.
J Pharmacol Sci 115(2):239-43. Epub 2011 Jan 26. 2011
22CASP4, TNFSF10
TRAIL-induced apoptosis of human melanoma cells involves activation of caspase-4.
Mao ZG, Jiang CC, Yang F, Thorne RF, Hersey P, Zhang XD.
Apoptosis 15(10):1211-22. doi: 10.1007/s10495-010-0513-9. 2010
23CASP1, CASP10, CASP14, CASP2, CASP3, CASP4, CASP5, CASP6, CASP7, CASP8, CASP9
Mutational analysis of CASP1, 2, 3, 4, 5, 6, 7, 8, 9, 10, and 14 genes in gastrointestinal stromal tumors.
Kim YR, Kim KM, Yoo NJ, Lee SH.
Hum Pathol 40(6):868-71. Epub 2009 Mar 9. 2009
24CASP4
Dual involvement of caspase-4 in inflammatory and ER stress-induced apoptotic responses in human retinal pigment epithelial cells.
Bian ZM, Elner SG, Elner VM.
Invest Ophthalmol Vis Sci. 50(12):6006-14. 2009
25APBB1, CASP4, TSHZ1, TSHZ2, TSHZ3
FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4.
Kajiwara Y, Akram A, Katsel P, Haroutunian V, Schmeidler J, Beecham G, Haines JL, Pericak-Vance MA, Buxbaum JD.
PLoS One 4(4):e5071. Epub 2009 Apr 3. 2009
26CASP1, CASP4, CASP5
Mutational analysis of caspase 1, 4, and 5 genes in common human cancers.
Soung YH, Jeong EG, Ahn CH, Kim SS, Song SY, Yoo NJ, Lee SH.
Hum Pathol 39(6):895-900. doi: 10.1016/j.humpath.2007.10.015. Epub 2008 Apr 21. 2008
27CASP4
Caspase-4 interacts with TNF receptor-associated factor 6 and mediates lipopolysaccharide-induced NF-kappaB-dependent production of IL-8 and CC chemokine ligand 4 (macrophage-inflammatory protein-1 ).
Lakshmanan U, Porter AG.
J Immunol. 179(12):8480-90. 2007
28PPT1, GAP43, CASP4
Endoplasmic reticulum stress-induced caspase-4 activation mediates apoptosis and neurodegeneration in INCL.
Kim SJ, Zhang Z, Hitomi E, Lee YC, Mukherjee AB.
Hum Mol Genet 15(11):1826-34. Epub 2006 Apr 27. 2006
29CASP4
Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death.
Hitomi J, Katayama T, Eguchi Y, Kudo T, Taniguchi M, Koyama Y, Manabe T, Yamagishi S, Bando Y, Imaizumi K, Tsujimoto Y, Tohyama M.
J Cell Biol. 165(3):347-56. 2004
30CASP1, CASP4, CASP5, CASP8
Structure and chromosome localization of the human CASP8 gene.
Grenet J, Teitz T, Wei T, Valentine V, Kidd VJ.
Gene 226(2):225-32. 1999
31CASP4
Caspase-1 (interleukin-1beta-converting enzyme) is inhibited by the human serpin analogue proteinase inhibitor 9.
Annand RR, Dahlen JR, Sprecher CA, De Dreu P, Foster DC, Mankovich JA, Talanian RV, Kisiel W, Giegel DA.
Biochem J. 342 Pt 3:655-65. 1999
32CASP4
Caspase-14 is a novel developmentally regulated protease.
Hu S, Snipas SJ, Vincenz C, Salvesen G, Dixit VM.
J Biol Chem. 273(45):29648-53. 1998
33CASP1, CASP4, CASP5
Interleukin-1beta-converting enzyme (ICE) and related cell death genes ICErel-II and ICErel-III map to the same PAC clone at band 11q22.2-22.3.
Nasir J, Theilmann JL, Vaillancourt JP, Munday NA, Ali A, Scherer S, Beatty B, Nicholson DW, Hayden MR.
Mamm Genome 8(8):611-3. 1997
34CASP1, CASP2, CASP3, CASP4, CASP6, CASP7
Caspases: intracellular signaling by proteolysis.
Salvesen GS, Dixit VM.
Cell 91(4):443-6. 1997
35CASP4
Involvement of caspase-4(-like) protease in Fas-mediated apoptotic pathway.
Kamada S, Washida M, Hasegawa J, Kusano H, Funahashi Y, Tsujimoto Y.
Oncogene. 15(3):285-90. 1997
36CASP3, CASP4, CASP5, FAS
Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis.
Enari M, Talanian RV, Wong WW, Nagata S.
Nature 380(6576):723-6. 1996
37CASP4
A novel human protease similar to the interleukin-1 beta converting enzyme induces apoptosis in transfected cells.
Faucheu C, et al.
EMBO J 14 : 1914-1922. 1995
38CASP4
Identification and characterization of ICH-2, a novel member of the interleukin-1 beta-converting enzyme family of cysteine proteases.
Kamens J, et al.
J Biol Chem 270 : 15250-15256. 1995
39CASP4, CASP5
Molecular cloning and pro-apoptotic activity of ICEre1II and ICEre1III, members of the ICE/CED-3 family of cysteine proteases.
Munday NA, et al.
J Biol Chem 270 : 15870-15876. 1995