| 1 | CASP4, IRF1, IRF1
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| IRF1 and IRF2 regulate the non-canonical inflammasome.
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| Thygesen SJ, Stacey KJ.
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| EMBO Rep 20(9):e48891. doi: 10.15252/embr.201948891. Epub 2019 Aug 5.
2019
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| 2 | CASP4, IRF2
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| A genome-wide screen identifies IRF2 as a key regulator of caspase-4 in human cells.
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| Benaoudia S, Martin A, Puig Gamez M, Gay G, Lagrange B, Cornut M, Krasnykov K, Claude JB, Bourgeois CF, Hughes S, Gillet B, Allatif O, Corbin A, Ricci R, Henry T.
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| EMBO Rep 20(9):e48235. doi: 10.15252/embr.201948235. Epub 2019 Jul 29.
2019
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| 3 | CASP4, GBP1
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| Human GBP1 is a microbe-specific gatekeeper of macrophage apoptosis and pyroptosis.
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| Fisch D, Bando H, Clough B, Hornung V, Yamamoto M, Shenoy AR, Frickel EM.
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| EMBO J 38(13):e100926. doi: 10.15252/embj.2018100926. Epub 2019 Jun 3.
2019
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| 4 | CASP4
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| CASP4 gene silencing in epithelial cancer cells leads to impairment of cell migration, cell-matrix adhesion and tissue invasion.
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| Papoff G, Presutti D, Lalli C, Bolasco G, Santini S, Manelfi C, Fustaino V, Alemà S, Ruberti G.
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| Sci Rep 8(1):17705. doi: 10.1038/s41598-018-35792-8.
2018
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| 5 | CASP4
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| CASP4/caspase-11 promotes autophagosome formation in response to bacterial infection.
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| Krause K, Caution K, Badr A, Hamilton K, Saleh A, Patel K, Seveau S, Hall-Stoodley L, Hegazi R, Zhang X, Gavrilin MA, Amer AO.
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| Autophagy 14(11):1928-1942. doi: 10.1080/15548627.2018.1491494. Epub 2018 Aug 31.
2018
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| 6 | CASP4
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| Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11.
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| Lagrange B, Benaoudia S, Wallet P, Magnotti F, Provost A, Michal F, Martin A, Di Lorenzo F, Py BF, Molinaro A, Henry T.
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| Nat Commun 9(1):242. doi: 10.1038/s41467-017-02682-y.
2018
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| 7 | CASP1, CASP4, IL1B
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| Involvement of caspase-4 in IL-1 beta production and pyroptosis in human macrophages during dengue virus infection.
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| Cheung KT, Sze DM, Chan KH, Leung PH.
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| Immunobiology 223(4-5):356-364. doi: 10.1016/j.imbio.2017.10.044. Epub 2017 Oct 26.
2018
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| 8 | CASP4, CTSG, IL1A
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| Caspase-4 activation by a bacterial surface protein is mediated by cathepsin G in human gingival fibroblasts.
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| Jun HK, Jung YJ, Ji S, An SJ, Choi BK.
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| Cell Death Differ 25(2):380-391. doi: 10.1038/cdd.2017.167. Epub 2017 Oct 27.
2018
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| 9 | CASP4, CASP5, SCAF11
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| High-affinity caspase-4 binding to LPS presented as high molecular mass aggregates or in outer membrane vesicles.
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| Wacker MA, Teghanemt A, Weiss JP, Barker JH.
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| Innate Immun 23(4):336-344. doi: 10.1177/1753425917695446. Epub 2017 Jan 1.
2017
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| 10 | CASP4, IFNA1
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| Interferon α Induces the Apoptosis of Cervical Cancer HeLa Cells by Activating both the Intrinsic Mitochondrial Pathway and Endoplasmic Reticulum Stress-Induced Pathway.
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| Shi WY, Cao C, Liu L.
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| Int J Mol Sci 17(11). pii: E1832.
2016
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| 11 | CASP4
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| The human-specific CASP4 gene product contributes to Alzheimer-related synaptic and behavioural deficits.
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| Kajiwara Y, McKenzie A, Dorr N, Gama Sosa MA, Elder G, Schmeidler J, Dickstein DL, Bozdagi O, Zhang B, Buxbaum JD.
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| Hum Mol Genet 25(19):4315-4327. doi: 10.1093/hmg/ddw265. Epub 2016 Aug 11.
2016
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| 12 | CASP3, CASP4
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| Proplatelet formation in megakaryocytes is associated with endoplasmic reticulum stress.
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| Morishima N, Nakanishi K.
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| Genes Cells 21(7):798-806. doi: 10.1111/gtc.12384. Epub 2016 Jun 14.
2016
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| 13 | CASP4, CASP5, IL1A, IL1B
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| Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes.
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| Viganò E, Diamond CE, Spreafico R, Balachander A, Sobota RM, Mortellaro A.
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| Nat Commun 6:8761. doi: 10.1038/ncomms9761.
2015
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| 14 | CASP4, NLRP3
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| Caspase-4 mediates non-canonical activation of the NLRP3 inflammasome in human myeloid cells.
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| Schmid-Burgk JL, Gaidt MM, Schmidt T, Ebert TS, Bartok E, Hornung V.
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| Eur J Immunol 45(10):2911-7. doi: 10.1002/eji.201545523. Epub 2015 Aug 6.
2015
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| 15 | CASP4
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| Human caspase-4 mediates noncanonical inflammasome activation against gram-negative bacterial pathogens.
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| Casson CN, Yu J, Reyes VM, Taschuk FO, Yadav A, Copenhaver AM, Nguyen HT, Collman RG, Shin S.
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| Proc Natl Acad Sci U S A 112(21):6688-93. doi: 10.1073/pnas.1421699112. Epub 2015 May 11.
2015
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| 16 | CASP4, CASP5
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| NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5.
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| Baker PJ, Boucher D, Bierschenk D, Tebartz C, Whitney PG, D'Silva DB, Tanzer MC, Monteleone M, Robertson AA, Cooper MA, Alvarez-Diaz S, Herold MJ, Bedoui S, Schroder K, Masters SL.
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| Eur J Immunol 45(10):2918-26. doi: 10.1002/eji.201545655. Epub 2015 Aug 24.
2015
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| 17 | CASP4
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| A critical role for human caspase-4 in endotoxin sensitivity.
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| Kajiwara Y, Schiff T, Voloudakis G, Gama Sosa MA, Elder G, Bozdagi O, Buxbaum JD.
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| J Immunol 193(1):335-43. doi: 10.4049/jimmunol.1303424. Epub 2014 May 30.
2014
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| 18 | CASP4, IL1B, TLR3
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| TLR3 mediates release of IL-1β and cell death in keratinocytes in a caspase-4 dependent manner.
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| Grimstad Ø, Husebye H, Espevik T.
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| J Dermatol Sci 72(1):45-53. doi: 10.1016/j.jdermsci.2013.05.006. Epub 2013 Jun 12.
2013
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| 19 | CASP4
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| Caspase-4 is required for activation of inflammasomes.
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| Sollberger G, Strittmatter GE, Kistowska M, French LE, Beer HD.
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| J Immunol 188(4):1992-2000. doi: 10.4049/jimmunol.1101620. Epub 2012 Jan 13.
2012
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| 20 | CASP4
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| Non-canonical inflammasome activation targets caspase-11.
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| Kayagaki N, Warming S, Lamkanfi M, Vande Walle L, Louie S, Dong J, Newton K, Qu Y, Liu J, Heldens S, Zhang J, Lee WP, Roose-Girma M, Dixit VM.
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| Nature. 479(7371):117-21. 2011
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| 21 | CASP4, CASP9
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| Caspase-4 directly activates caspase-9 in endoplasmic reticulum stress-induced apoptosis in SH-SY5Y cells.
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| Yamamuro A, Kishino T, Ohshima Y, Yoshioka Y, Kimura T, Kasai A, Maeda S.
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| J Pharmacol Sci 115(2):239-43. Epub 2011 Jan 26.
2011
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| 22 | CASP4, TNFSF10
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| TRAIL-induced apoptosis of human melanoma cells involves activation of caspase-4.
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| Mao ZG, Jiang CC, Yang F, Thorne RF, Hersey P, Zhang XD.
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| Apoptosis 15(10):1211-22. doi: 10.1007/s10495-010-0513-9.
2010
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| 23 | CASP1, CASP10, CASP14, CASP2, CASP3, CASP4, CASP5, CASP6, CASP7, CASP8, CASP9
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| Mutational analysis of CASP1, 2, 3, 4, 5, 6, 7, 8, 9, 10, and 14 genes in gastrointestinal stromal tumors.
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| Kim YR, Kim KM, Yoo NJ, Lee SH.
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| Hum Pathol 40(6):868-71. Epub 2009 Mar 9.
2009
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| 24 | CASP4
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| Dual involvement of caspase-4 in inflammatory and ER stress-induced apoptotic responses in human retinal pigment epithelial cells.
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| Bian ZM, Elner SG, Elner VM.
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| Invest Ophthalmol Vis Sci. 50(12):6006-14. 2009
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| 25 | APBB1, CASP4, TSHZ1, TSHZ2, TSHZ3
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| FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4.
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| Kajiwara Y, Akram A, Katsel P, Haroutunian V, Schmeidler J, Beecham G, Haines JL, Pericak-Vance MA, Buxbaum JD.
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| PLoS One 4(4):e5071. Epub 2009 Apr 3.
2009
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| 26 | CASP1, CASP4, CASP5
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| Mutational analysis of caspase 1, 4, and 5 genes in common human cancers.
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| Soung YH, Jeong EG, Ahn CH, Kim SS, Song SY, Yoo NJ, Lee SH.
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| Hum Pathol 39(6):895-900. doi: 10.1016/j.humpath.2007.10.015. Epub 2008 Apr 21.
2008
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| 27 | CASP4
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| Caspase-4 interacts with TNF receptor-associated factor 6 and mediates lipopolysaccharide-induced NF-kappaB-dependent production of IL-8 and CC chemokine ligand 4 (macrophage-inflammatory protein-1 ).
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| Lakshmanan U, Porter AG.
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| J Immunol. 179(12):8480-90. 2007
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| 28 | PPT1, GAP43, CASP4
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| Endoplasmic reticulum stress-induced caspase-4 activation mediates apoptosis and neurodegeneration in INCL.
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| Kim SJ, Zhang Z, Hitomi E, Lee YC, Mukherjee AB.
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| Hum Mol Genet 15(11):1826-34. Epub 2006 Apr 27. 2006
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| 29 | CASP4
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| Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death.
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| Hitomi J, Katayama T, Eguchi Y, Kudo T, Taniguchi M, Koyama Y, Manabe T, Yamagishi S, Bando Y, Imaizumi K, Tsujimoto Y, Tohyama M.
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| J Cell Biol. 165(3):347-56. 2004
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| 30 | CASP1, CASP4, CASP5, CASP8
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| Structure and chromosome localization of the human CASP8 gene.
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| Grenet J, Teitz T, Wei T, Valentine V, Kidd VJ.
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| Gene 226(2):225-32. 1999
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| 31 | CASP4
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| Caspase-1 (interleukin-1beta-converting enzyme) is inhibited by the human serpin analogue proteinase inhibitor 9.
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| Annand RR, Dahlen JR, Sprecher CA, De Dreu P, Foster DC, Mankovich JA, Talanian RV, Kisiel W, Giegel DA.
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| Biochem J. 342 Pt 3:655-65. 1999
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| 32 | CASP4
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| Caspase-14 is a novel developmentally regulated protease.
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| Hu S, Snipas SJ, Vincenz C, Salvesen G, Dixit VM.
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| J Biol Chem. 273(45):29648-53. 1998
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| 33 | CASP1, CASP4, CASP5
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| Interleukin-1beta-converting enzyme (ICE) and related cell death genes ICErel-II and ICErel-III map to the same PAC clone at band 11q22.2-22.3.
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| Nasir J, Theilmann JL, Vaillancourt JP, Munday NA, Ali A, Scherer S, Beatty B, Nicholson DW, Hayden MR.
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| Mamm Genome 8(8):611-3. 1997
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| 34 | CASP1, CASP2, CASP3, CASP4, CASP6, CASP7
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| Caspases: intracellular signaling by proteolysis.
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| Salvesen GS, Dixit VM.
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| Cell 91(4):443-6. 1997
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| 35 | CASP4
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| Involvement of caspase-4(-like) protease in Fas-mediated apoptotic pathway.
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| Kamada S, Washida M, Hasegawa J, Kusano H, Funahashi Y, Tsujimoto Y.
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| Oncogene. 15(3):285-90. 1997
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| 36 | CASP3, CASP4, CASP5, FAS
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| Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis.
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| Enari M, Talanian RV, Wong WW, Nagata S.
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| Nature 380(6576):723-6. 1996
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| 37 | CASP4
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| A novel human protease similar to the interleukin-1 beta converting enzyme induces apoptosis in transfected cells.
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| Faucheu C, et al.
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| EMBO J 14 : 1914-1922. 1995
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| 38 | CASP4
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| Identification and characterization of ICH-2, a novel member of the interleukin-1 beta-converting enzyme family of cysteine proteases.
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| Kamens J, et al.
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| J Biol Chem 270 : 15250-15256. 1995
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| 39 | CASP4, CASP5
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| Molecular cloning and pro-apoptotic activity of ICEre1II and ICEre1III, members of the ICE/CED-3 family of cysteine proteases.
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| Munday NA, et al.
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| J Biol Chem 270 : 15870-15876. 1995
|