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FLASH GENE

Symbol

RHEB

contributors: mct/pgu - updated : 04-09-2018

HGNC name	Ras homolog enriched in brain
HGNC id	10011

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   amplification     in human prostate cancers constitutional     --low   inhibited the monocyte-to-macrophage differentiation process constitutional     --low   RHEB levels are down-regulated in the Alzheimer disease brain, which is consistent with an increased BACE1 expression

Susceptibility

Variant & Polymorphism

Candidate gene	for holoprosencephaly type 3 and/or sacral agenesis
Marker
Therapy target

ANIMAL & CELL MODELS

absolute number of macrophages decreased in the bone marrow (BM) of Rheb1-deficient mice