| 1 | BRAF, MTOR, RHEB
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| An oncogenic mutant of RHEB, RHEB Y35N, exhibits an altered interaction with BRAF resulting in cancer transformation.
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| Heard JJ, Phung I, Potes MI, Tamanoi F.
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| BMC Cancer 18(1):69. doi: 10.1186/s12885-017-3938-5.
2018
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| 2 | MTOR, RHEB, RPTOR
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| Distinct roles of Rheb and Raptor in activating mTOR complex 1 for the self-renewal of hematopoietic stem cells.
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| Peng H, Kasada A, Ueno M, Hoshii T, Tadokoro Y, Nomura N, Ito C, Takase Y, Vu HT, Kobayashi M, Xiao B, Worley PF, Hirao A.
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| Biochem Biophys Res Commun 495(1):1129-1135. doi: 10.1016/j.bbrc.2017.11.140. Epub 2017 Nov 22.
2018
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| 3 | AKT1S1, MTOR, RHEB
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| Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.
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| Yang H, Jiang X, Li B, Yang HJ, Miller M, Yang A, Dhar A, Pavletich NP.
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| Nature 552(7685):368-373. doi: 10.1038/nature25023. Epub 2017 Dec 13.
2017
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| 4 | RHEB
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| RHEB: a potential regulator of chondrocyte phenotype for cartilage tissue regeneration.
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| Ashraf S, Ahn J, Cha BH, Kim JS, Han I, Park H, Lee SH.
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| J Tissue Eng Regen Med 11(9):2503-2515. doi: 10.1002/term.2148. Epub 2016 Apr 6.
2017
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| 5 | RASSF1, RHEB
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| Rheb may complex with RASSF1A to coordinate Hippo and TOR signaling.
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| Nelson N, Clark GJ.
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| Oncotarget 7(23):33821-31. doi: 10.18632/oncotarget.8447.
2016
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| 6 | MTOR, RHEB
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| Rheb1-mTORC1 maintains macrophage differentiation and phagocytosis in mice.
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| Wang X, Li M, Gao Y, Gao J, Yang W, Liang H, Ji Q, Li Y, Liu H, Huang J, Cheng T, Yuan W.
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| Exp Cell Res 344(2):219-28. doi: 10.1016/j.yexcr.2016.04.017. Epub 2016 May 7.
2016
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| 7 | RHEB
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| RHEB1 expression in embryonic and postnatal mouse.
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| Tian Q, Smart JL, Clement JH, Wang Y, Derkatch A, Schubert H, Danilchik MV, Marks DL, Fedorov LM.
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| Histochem Cell Biol 145(5):561-72. doi: 10.1007/s00418-015-1394-3. Epub 2015 Dec 26.
2016
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| 8 | RHEB, SDCBP
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| Rheb activation disrupts spine synapse formation through accumulation of syntenin in tuberous sclerosis complex.
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| Sugiura H, Yasuda S, Katsurabayashi S, Kawano H, Endo K, Takasaki K, Iwasaki K, Ichikawa M, Kobayashi T, Hino O, Yamagata K.
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| Nat Commun 6:6842. doi: 10.1038/ncomms7842.
2015
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| 9 | CAD, RHEB, RHEBL1
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| Rheb protein binds CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamoylase, and dihydroorotase) protein in a GTP- and effector domain-dependent manner and influences its cellular localization and carbamoyl-phosphate synthetase (CPSase) activity.
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| Sato T, Akasu H, Shimono W, Matsu C, Fujiwara Y, Shibagaki Y, Heard JJ, Tamanoi F, Hattori S.
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| J Biol Chem 290(2):1096-105. doi: 10.1074/jbc.M114.592402. Epub 2014 Nov 24.
2015
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| 10 | MTOR, RHEB
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| The small GTPase Rheb is required for spermatogenesis but not oogenesis.
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| Baker MD, Ezzati M, Aloisio GM, Tarnawa ED, Cuevas I, Nakada Y, Castrillon DH.
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| Reproduction 147(5):615-25. doi: 10.1530/REP-13-0304. Print 2014 May.
2014
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| 11 | BACE1, RHEB
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| Rheb GTPase regulates β-secretase levels and amyloid β generation.
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| Shahani N, Pryor W, Swarnkar S, Kholodilov N, Thinakaran G, Burke RE, Subramaniam S.
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| J Biol Chem 289(9):5799-808. doi: 10.1074/jbc.M113.532713. Epub 2013 Dec 24.
2014
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| 12 | RHEB, RHEBL1
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| Effects of RhebL1 silencing on the mTOR pathway.
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| Bonneau A, Parmar N.
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| Mol Biol Rep 39(3):2129-37. doi: 10.1007/s11033-011-0960-6. Epub 2011 Jun 8.
2012
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| 13 | MTOR, RHEB
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| Rheb1 is required for mTORC1 and myelination in postnatal brain development.
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| Zou J, Zhou L, Du XX, Ji Y, Xu J, Tian J, Jiang W, Zou Y, Yu S, Gan L, Luo M, Yang Q, Cui Y, Yang W, Xia X, Chen M, Zhao X, Shen Y, Chen PY, Worley PF, Xiao B.
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| Dev Cell 20(1):97-108. doi: 10.1016/j.devcel.2010.11.020.
2011
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| 14 | IRS1, MTOR, RHEB, RPTOR
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| Raptor and Rheb negatively regulate skeletal myogenesis through suppression of insulin receptor substrate 1 (IRS1).
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| Ge Y, Yoon MS, Chen J.
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| J Biol Chem 286(41):35675-82. doi: 10.1074/jbc.M111.262881. Epub 2011 Aug 18.
2011
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| 15 | MAPKAPK5, RHEB
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| Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1.
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| Zheng M, Wang YH, Wu XN, Wu SQ, Lu BJ, Dong MQ, Zhang H, Sun P, Lin SC, Guan KL, Han J.
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| Nat Cell Biol 13(3):263-72. doi: 10.1038/ncb2168. Epub 2011 Feb 20.
2011
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| 16 | RHEB, RHEBL1
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| Differential requirement of CAAX-mediated posttranslational processing for Rheb localization and signaling.
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| Hanker AB, Mitin N, Wilder RS, Henske EP, Tamanoi F, Cox AD, Der CJ.
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| Oncogene 29(3):380-91. doi: 10.1038/onc.2009.336. Epub 2009 Oct 19.
2010
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| 17 | FKBP8, MTOR, RHEB
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| Reassessment of the role of FKBP38 in the Rheb/mTORC1 pathway.
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| Uhlenbrock K, Weiwad M, Wetzker R, Fischer G, Wittinghofer A, Rubio I.
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| FEBS Lett 583(6):965-70. Epub 2009 Feb 15. 2009
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| 18 | RHEB
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| Aberrant Rheb-mediated mTORC1 activation and Pten haploinsufficiency are cooperative oncogenic events.
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| Nardella C, Chen Z, Salmena L, Carracedo A, Alimonti A, Egia A, Carver B, Gerald W, Cordon-Cardo C, Pandolfi PP.
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| Genes Dev 22(16):2172-7.
2008
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| 19 | FKBP8, RHEB
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| The switch I region of Rheb is critical for its interaction with FKBP38.
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| Ma D, Bai X, Guo S, Jiang Y.
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| J Biol Chem 283(38):25963-70. Epub 2008 Jul 25.
2008
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| 20 | MTOR, RHEB
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| mTOR is activated in the majority of malignant melanomas.
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| Karbowniczek M, Spittle CS, Morrison T, Wu H, Henske EP.
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| J Invest Dermatol 128(4):980-7. Epub 2007 Oct 4.PMID: 17914450 2008
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| 21 | FKBP8, MTOR, RHEB
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| Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38.
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| Bai X, Ma D, Liu A, Shen X, Wang QJ, Liu Y, Jiang Y.
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| Science 318(5852):977-80. 2007
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| 22 | RHEB
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| The Rheb switch 2 segment is critical for signaling to target of rapamycin complex 1.
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| Long X, Lin Y, Ortiz-Vega S, Busch S, Avruch J.
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| J Biol Chem 282(25):18542-51. Epub 2007 Apr 30.
2007
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| 23 | MTOR, RHEB
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| Localization of Rheb to the endomembrane is critical for its signaling function.
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| Buerger C, DeVries B, Stambolic V.
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| Biochem Biophys Res Commun 344(3):869-80. Epub 2006 Apr 19. 2006
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| 24 | MTOR, RHEB
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| Rheb binds and regulates the mTOR kinase.
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| Long X, Lin Y, Ortiz-Vega S, Yonezawa K, Avruch J.
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| Curr Biol 15(8):702-13. 2005
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| 25 | RHEB
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| Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K.
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| Tabancay AP Jr, Gau CL, Machado IM, Uhlmann EJ, Gutmann DH, Guo L, Tamanoi F.
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| J Biol Chem 278(41):39921-30. Epub 2003 Jul 17. 2003
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| 26 | RHEB, TSC1, TSC2
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| Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner.
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| Castro AF, Rebhun JF, Clark GJ, Quilliam LA.
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| J Biol Chem 278(35):32493-6. Epub 2003 Jul 03. 2003
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| 27 | RHEB, TSC2
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| Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling.
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| Inoki K, Li Y, Xu T, Guan KL.
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| Genes Dev 17(15):1829-34. Epub 2003 Jul 17. 2003
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| 28 | PRKAG2, RHEB
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| Molecular cloning, genomic organization, and mapping of PRKAG2, a heart abundant gamma2 subunit of 5'-AMP-activated protein kinase, to human chromosome 7q36.
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| Lang T, Yu L, Tu Q, Jiang J, Chen Z, Xin Y, Liu G, Zhao S.
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| Genomics 70(2):258-63. 2000
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| 29 | ACYP2, ADCK2, C1GALT1, C7orf24, CCZ1, CD207, CDK7PS, CEP68, CREB5, CRYGN, EEF1DP4, FAM115D, FOXD4L2, GLCCI1, H2AFV, HDHD1BP, HIBADH, HSPA9P, ITGB1BP1, KIAA0319L, KLHL13, KLHL7, KLHL9, KRT18P51, LSM8, MBTPS2, NACA3P, NCDN, NDUFB8P1, NPM1P12, NT5C3P1, NT5CP1, NT5CP2, NXPH1, OR10AC1P, OR10AH1P, OR2A12, OR2A2, OR2A3P, OR2AE1, OR2E1P, OR2Q1P, OR2T1, OR4D12P, OR4F1P, OR4F7P, OR5M14P, OR5S1P, OR6B1, OR6B2, OR6B3, OR6V1, OR6W1P, OR7E1P, OR7E28P, OR7E38P, OR7E46P, OR7E62P, OR7E7P, OR7E83P, OR7E84P, OR7E85P, OR7E86P, OR7E91P, OR7E93P, OR7E99P, OR9P1P, PCDH11Y, PDAP1, PGBD3P4, POLR2J2, PPIL1P1, PSMA6P, PTTG4P, PURB, RASA4, RHEB, RNU56B, RPL22, RPL36AP3, RPL41P4, RPS2P2, SCIN, SEC14L4, STARD3NL, TIGD4, ZNHIT4
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| Toward a complete human genome sequence.
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| No authors listed.
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| Genome Res 8(11):1097-108. 1998
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| 30 | RHEB
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| Isolation of cDNA and genomic clones of a human ras-related GTP-binding protein gene and its chromosomal localization to the long arm of chromosome 7, 7q36.
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| Mizuki N, et al.
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| Genomics 34 : 114-118. 1996
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| 31 | RHEBP1, RHEB
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| A novel approach for expression cloning of small GTPases : identification, tissue distribution and chromosome mapping of the human homolog of rheb.
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| Gromov PS, et al.
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| FEBS Lett 377 : 221-226. 1995
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| 32 | RHEB, RHEBP1
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| rheb, a growth factor- and synaptic activity-regulated gene, encodes a novel Ras-related protein.
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| Yamagata K, Sanders LK, Kaufmann WE, Yee W, Barnes CA, Nathans D, WorleyPF.
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| J Biol Chem 269(23):16333-9. 1994
|