SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,organelle,lysosome
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| intracellular,cytoplasm,cytosolic
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| text
| lipid-anchorto the cytoplasmic side |
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RHEB and RHEBL1 localize primarily to the endoplasmic reticulum and Golgi apparatus  |
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RHEB is activated at the Golgi from where it will travel to lysosomes |
| basic FUNCTION
| exhibiting intrinsic GTPase activity |
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may control growth |
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promoting mTOR-dependent S6 kinase activation in a rapamycin- and farnesylation-dependent manner |
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stimulating phosphorylation of 4EBP1 |
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playing an important role in cellular responses to energy limitation and nutrient starvation |
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may also control BCL2-dependent apoptosis and calcineurin-dependent transcription through FKBP8 |
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activating FRAP1 by antagonizing its endogenous inhibitor, FKBP8 |
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playing a vital role in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway |
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directly activating MTOR, in a farnesylation-dependent manner |
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critical for embryonic survival and MTOR signaling |
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essential for MTOR signaling and myelination in the brain, suggesting that MTOR signaling plays a role in selective cellular adaptations, rather than general cellular viability |
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negatively regulates myoblast differentiation through suppression of IRS1 and inhibition of AKT activation |
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function of RPTOR and RHEB in myogenesis is mediated by IRS1 |
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essential role of RHEB in diverse aspects of spermatogenesis, suggesting the existence of functionally redundant factors that can compensate for RHEB deficiency within oocytes |
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oligodendrocyte progenitor cells (OPCs) -intrinsic MTOR activity mediated by RHEB is critical for differentiation of OPCs to mature oligodendrocytes, but that mature oligodendrocytes do not require RHEB to make myelin or maintain it in the adult brain |
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possible role of RHEB and RHEBL1 in regulating de novo pyrimidine nucleotide synthesis |
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expression pattern of RHEB suggests that it likely plays a ubiquitous role in the development of the early embryo with more tissue-specific roles in later development |
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RHEB induces a distinct gene expression signature that maintained the innate chondrogenic properties over a long period |
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is critical for macrophage production and phagocytosis and executes these activities possibly via MTOR-dependent pathway |
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distinct roles of RHEB and RPTOR in activating MTOR for the self-renewal of hematopoietic stem cells |
