| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| constitutional
|
|
| --low
|
|
silencing reduces inflammatory response and increases insulin sensitivity in adipose tissue  | | constitutional
|
|
| --low
|
| |
down-regulation affects DNA replication rate, increases the number of simultaneously firing origins and the asymmetry of DNA replication, leading to DNA damage | | constitutional
|
|
|
| loss of function
| |
results in the accumulation of lineage-committed progenitors, increased monocyte/macrophage differentiation and arrested erythroid maturation | |
