| 1 | DDDFD, MN1, PBX1, PKNOX1, ZBTB24
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| Gain-of-Function MN1 Truncation Variants Cause a Recognizable Syndrome with Craniofacial and Brain Abnormalities.
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| Miyake N, Takahashi H, Nakamura K, Isidor B, Hiraki Y, Koshimizu E, Shiina M, Sasaki K, Suzuki H, Abe R, Kimura Y, Akiyama T, Tomizawa SI, Hirose T, Hamanaka K, Miyatake S, Mitsuhashi S, Mizuguchi T, Takata A, Obo K, Kato M, Ogata K, Matsumoto N.
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| Am J Hum Genet 106(1):13-25. doi: 10.1016/j.ajhg.2019.11.011. Epub 2019 Dec 12.
2020
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| 2 | PKNOX1, SNAI2
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| Prep1 (pKnox1) transcription factor contributes to pubertal mammary gland branching morphogenesis.
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| Sicouri L, Pisati F, Pece S, Blasi F, Longobardi E.
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| Int J Dev Biol 62(11-12):827-836. doi: 10.1387/ijdb.180278fb.
2018
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| 3 | PKNOX1
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| The genetics and the molecular functions of the PREP1 homeodomain transcription factor.
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| Purushothaman D, Blasi F.
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| Int J Dev Biol 62(11-12):819-825. doi: 10.1387/ijdb.180238fb. Review.
2018
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| 4 | PKNOX1
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| Prep1 deficiency improves metabolic response in white adipose tissue.
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| Liotti A, Cabaro S, Cimmino I, Ricci S, Procaccini C, Paciello O, Raciti GA, Spinelli R, Iossa S, Matarese G, Miele C, Formisano P, Beguinot F, Oriente F.
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| Biochim Biophys Acta Mol Cell Biol Lipids 1863(5):515-525. doi: 10.1016/j.bbalip.2018.02.005. Epub 2018 Feb 21.
2018
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| 5 | PKNOX1
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| PREP1 tumor suppressor protects the late-replicating DNA by controlling its replication timing and symmetry.
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| Palmigiano A, Santaniello F, Cerutti A, Penkov D, Purushothaman D, Makhija E, Luzi L, di Fagagna FD, Pelicci PG, Shivashankar V, Dellino GI, Blasi F.
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| Sci Rep 8(1):3198. doi: 10.1038/s41598-018-21363-4.
2018
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| 6 | PKNOX1
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| Germ cell-intrinsic requirement for the homeodomain transcription factor PKnox1/Prep1 in adult spermatogenesis.
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| Kawai Y, Oda A, Kanai Y, Goitsuka R.
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| PLoS One 13(1):e0190702. doi: 10.1371/journal.pone.0190702. eCollection 2018.
2018
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| 7 | PKNOX1
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| Prep1 prevents premature adipogenesis of mesenchymal progenitors.
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| Maroni G, Tkachuk VA, Egorov A, Morelli MJ, Luongo R, Levantini E, Blasi F, Magli MC, Penkov D.
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| Sci Rep 7(1):15573. doi: 10.1038/s41598-017-15828-1.
2017
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| 8 | PBX1, PKNOX1
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| New Insights into Cooperative Binding of Homeodomain Transcription Factors PREP1 and PBX1 to DNA.
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| Zucchelli C, Ferrari E, Blasi F, Musco G, Bruckmann C.
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| Sci Rep 7:40665. doi: 10.1038/srep40665.
2017
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| 9 | FOXO1, PKNOX1
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| The transcription factor Prep1 controls hepatic insulin sensitivity and gluconeogenesis by targeting nuclear localization of FOXO1.
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| Kulebyakin K, Penkov D, Blasi F, Akopyan Z, Tkachuk V.
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| Biochem Biophys Res Commun 481(1-2):182-188. doi: 10.1016/j.bbrc.2016.10.146. Epub 2016 Nov 1.
2016
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| 10 | PKNOX1
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| Loss of the Homeodomain Transcription Factor Prep1 Perturbs Adult Hematopoiesis in the Bone Marrow.
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| Yoshioka K, Oda A, Notsu C, Ohtsuka T, Kawai Y, Suzuki S, Nakamura T, Mabuchi Y, Matsuzaki Y, Goitsuka R.
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| PLoS One 10(8):e0136107. doi: 10.1371/journal.pone.0136107. eCollection 2015.
2015
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| 11 | MEIS1, PBX1, PKNOX1
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| Prep1 and Meis1 competition for Pbx1 binding regulates protein stability and tumorigenesis.
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| Dardaei L, Longobardi E, Blasi F.
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| Proc Natl Acad Sci U S A 111(10):E896-905. doi: 10.1073/pnas.1321200111. Epub 2014 Feb 27.
2014
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| 12 | PKNOX1
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| Pknox1/Prep1 regulates mitochondrial oxidative phosphorylation components in skeletal muscle.
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| Kanzleiter T, Rath M, Penkov D, Puchkov D, Schulz N, Blasi F, Schürmann A.
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| Mol Cell Biol 34(2):290-8. doi: 10.1128/MCB.01232-13. Epub 2013 Nov 11.
2014
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| 13 | MEIS1, PBX1, PKNOX1
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| Characterization of TALE genes expression during the first lineage segregation in mammalian embryos.
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| Sonnet W, Rezsöhazy R, Donnay I.
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| Dev Dyn 241(11):1827-39. doi: 10.1002/dvdy.23873. Epub 2012 Oct 10.
2012
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| 14 | MEIS1, PKNOX1
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| The functional role of the Meis/Prep-binding elements in Pax6 locus during pancreas and eye development.
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| Carbe C, Hertzler-Schaefer K, Zhang X.
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| Dev Biol 363(1):320-9. doi: 10.1016/j.ydbio.2011.12.038. Epub 2012 Jan 3.
2012
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| 15 | MEIS1, PKNOX1
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| C-terminal domain of MEIS1 converts PKNOX1 (PREP1) into a HOXA9-collaborating oncoprotein.
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| Bisaillon R, Wilhelm BT, Krosl J, Sauvageau G.
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| Blood 118(17):4682-9. doi: 10.1182/blood-2011-05-354076. Epub 2011 Sep 7.
2011
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| 16 | PKNOX1
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| Homeodomain transcription factor and tumor suppressor Prep1 is required to maintain genomic stability.
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| Iotti G, Longobardi E, Masella S, Dardaei L, De Santis F, Micali N, Blasi F.
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| Proc Natl Acad Sci U S A 108(29):E314-22. doi: 10.1073/pnas.1105216108. Epub 2011 Jun 29.
2011
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| 17 | PKNOX1, PTPN6
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| Prep1 controls insulin glucoregulatory function in liver by transcriptional targeting of SHP1 tyrosine phosphatase.
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| Oriente F, Iovino S, Cabaro S, Cassese A, Longobardi E, Miele C, Ungaro P, Formisano P, Blasi F, Beguinot F.
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| Diabetes 60(1):138-47. doi: 10.2337/db10-0860. Epub 2010 Sep 23.
2011
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| 18 | PKNOX1
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| Characterization of the regulatory region of the zebrafish Prep1.1 gene: analogies to the promoter of the human PREP1.
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| Bernardi E, Deflorian G, Pezzimenti F, Diaz VM, Mione M, Blasi F.
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| PLoS One 5(12):e15047. doi: 10.1371/journal.pone.0015047. Erratum in: PLoS One. 2011;6(4). doi:10.1371/annotation/6de90ec9-0314-40ec-b634 2010
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| 19 | EIF4E2, PKNOX1
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| Cytoplasmic Prep1 interacts with 4EHP inhibiting Hoxb4 translation.
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| Villaescusa JC, Buratti C, Penkov D, Mathiasen L, Planagumà J, Ferretti E, Blasi F.
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| PLoS One 4(4):e5213. doi: 10.1371/journal.pone.0005213. Epub 2009 Apr 13.
2009
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| 20 | PKNOX1
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| Cytosolic sequestration of Prep1 influences early stages of T cell development.
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| Penkov D, Palazzolo M, Mondino A, Blasi F.
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| PLoS One 3(6):e2424. doi: 10.1371/journal.pone.0002424.
2008
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| 21 | PKNOX1
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| Prep1 deficiency induces protection from diabetes and increased insulin sensitivity through a p160-mediated mechanism.
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| Oriente F, Fernandez Diaz LC, Miele C, Iovino S, Mori S, Diaz VM, Troncone G, Cassese A, Formisano P, Blasi F, Beguinot F.
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| Mol Cell Biol 28(18):5634-45. doi: 10.1128/MCB.00117-08. Epub 2008 Jul 21.
2008
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| 22 | PKNOX1
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| The homeodomain transcription factor Prep1 (pKnox1) is required for hematopoietic stem and progenitor cell activity.
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| Di Rosa P, Villaescusa JC, Longobardi E, Iotti G, Ferretti E, Diaz VM, Miccio A, Ferrari G, Blasi F.
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| Dev Biol 311(2):324-34. Epub 2007 Aug 24.
2007
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| 23 | PBX1, PKNOX1
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| Activin regulation of the follicle-stimulating hormone beta-subunit gene involves Smads and the TALE homeodomain proteins Pbx1 and Prep1.
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| Bailey JS, Rave-Harel N, McGillivray SM, Coss D, Mellon PL.
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| Mol Endocrinol 18(5):1158-70. Epub 2004 Feb 5.
2004
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| 24 | PKNOX1, MEIS1, PF4
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| PREP1, MEIS1 homolog protein, regulates PF4 gene expression.
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| Okada Y, Matsuura E, Nagai R, Sato T, Watanabe A, Morita I, Doi T.
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| Biochem Biophys Res Commun 305(1):155-9. 2003
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| 25 | PKNOX1
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| PKNOX1, a gene encoding PREP1, a new regulator of Pbx activity, maps on human chromosome 21q22.3 and murine chromosome 17B/C.
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| Berthelsen J, Viggiano L, Schulz H, Ferretti E, Consalez GG, Rocchi M, Blasi F.
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| Genomics 47(2):323-4. 1998
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| 26 | PKNOX1
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| Cloning of a novel homeobox-containing gene, PKNOX1, and mapping to human chromosome 21q22.3
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| Chen H, et al.
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| Genomics 41 : 193-200. 1997
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| 27 | PKNOX1
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| VEF3-p64 gene, encoding a new homeo-protein binding PBX1, maps in the distal region of 21q. (abstr)
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| Berthelsen J, et al.
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| Cytogenet Cell Genet 79 : 41. 1997
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| 28 | MEIS1, MEIS2, MEIS3, PBX2, PBX3, PKNOX1
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| Analysis of TALE superclass homeobox genes (MEIS, PBC, KNOX, Iroquois, TGIF) reveals a novel domain conserved between plants and animals.
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| Burglin TR.
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| Nucleic Acids Res 25(21):4173-80 1997
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| 29 | PKNOX1
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| Purification and characterization of UEF3, a novel factor involved in the regulation of the urokinase and other AP-1 controlled promoters.
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| Berthelsen J, Vandekerkhove J, Blasi F.
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| J Biol Chem 271(7):3822-30. 1996
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