| basic FUNCTION
| chloride voltage-gated channel regulatory protein |
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regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume |
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exhibits both nuclear and plasma membrane chloride ion channel activity |
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actin-regulated membrane protein that could modify solute transport at key stages during cellular events such as apoptosis, cell and organelle division and fusion, cell-volume regulation, and cell movement |
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may play a role in the regulation of osteoblastic differentiation from mesenchymal progenitors  |
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acting as both a second messenger and an executor during oxidative stress |
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forms oligomers upon oxidation in the presence of the membranes |
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involved in the lymphatic metastasis of tumors |
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important role for CLIC1 in regulating macrophage function through its ion channel activity, suggesting it is a suitable target for the development of anti-inflammatory drug |
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having the ability to spontaneously insert into lipid membranes from a soluble, globular state |
