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FLASH GENE

Symbol

CLIC1

contributors: mct/pgu - updated : 05-11-2013

HGNC name	chloride intracellular channel 1
HGNC id	2062

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	6.74 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001288 6 - 1265 NP_001279 - 241 - 2010 : 200857

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive pharynx       highly   stomach       highly Respiratory lung       highly Urinary kidney nephron       Visual eye anterior segment cornea

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     highly Muscular smooth       Muscular striatum cardiac     Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminal domain of CLIC1 is likely to insert into the lipid bilayer
	C-domain remaining in solution on the extravesicular side of the membrane

mono polymer

homomer , monomer , dimer

HOMOLOGY

interspecies

homolog to murine Clic1

Homologene

FAMILY	glutathione S transferase fold family
	CLIC family of chloride channels

CATEGORY

transport channel

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,nucleus
	intracellular,nuclear envelope
text	nuclear membrane brush border of renal PCT
	following microglial activation, CLIC1 translocates from cytosol to plasma membrane where it promotes a chloride conductance

basic FUNCTION	chloride voltage-gated channel regulatory protein
	regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume
	exhibits both nuclear and plasma membrane chloride ion channel activity
	actin-regulated membrane protein that could modify solute transport at key stages during cellular events such as apoptosis, cell and organelle division and fusion, cell-volume regulation, and cell movement
	may play a role in the regulation of osteoblastic differentiation from mesenchymal progenitors
	acting as both a second messenger and an executor during oxidative stress
	forms oligomers upon oxidation in the presence of the membranes
	involved in the lymphatic metastasis of tumors
	important role for CLIC1 in regulating macrophage function through its ion channel activity, suggesting it is a suitable target for the development of anti-inflammatory drug
	having the ability to spontaneously insert into lipid membranes from a soluble, globular state

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interacting with TRAPPC2

cell & other

REGULATION

inhibited by

strongly and reversibly inhibited (or inactivated) by cytosolic F-actin in the absence of any other protein

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer brain glioma/neuroblstoma potential target and prognostic biomarker

ANIMAL & CELL MODELS

Clic1(-/-) murine macrophages displayed impaired phagosomal proteolytic capacity and reduced reactive oxygen species production