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FLASH GENE
Symbol TNNI2 contributors: mct/npt/pgu - updated : 28-12-2016
HGNC name troponin I type 2 (skeletal, fast)
HGNC id 11946
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Tnni2
homolog to C.elegans W03F8.1
intraspecies homolog to TNNI1
homolog to TNNI3
Homologene
FAMILY
  • troponin I family
    • CATEGORY motor/contractile , regulatory , structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • preventing actin and myosin interaction in resting muscle tissue
  • involved in the regulation of muscle contraction
  • may be playing a role in regulation of smooth muscle function
  • playing potentially a role in regulation of smooth muscle function
  • inhibitory subunit of the troponin complex in the sarcomeric thin filament of striated muscle and plays a central role in the calcium regulation of contraction and relaxation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • inhibitory subunit of troponin
  • Troponin consists of three subunits: an inhibitory subunit TNNI2, a Ca2+-binding subunit TNNC2, and TNNT2
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to actin-tropomyosin
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) AMCD2B
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS