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FLASH GENE
Symbol TNNI2 contributors: mct/npt/pgu - updated : 28-12-2016
HGNC name troponin I type 2 (skeletal, fast)
HGNC id 11946
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem
text organized in pair with TNNT3
STRUCTURE 2.01 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence
text structure putative regulatory element in the 5'region and a region containing MEF2, E-box, CCAC and CAGG element
MAPPING cloned Y linked N status confirmed
Map pter - TNNI2 - D11S922 - D11S932 - D11S1350 - cen
regionally located tightly linked to TNNT2 and ELF3
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 700 21.21 182 - 2008 18548613
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestivepharynx    
Nervousnerve    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumcardiac  
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Tnni2
homolog to C.elegans W03F8.1
intraspecies homolog to TNNI1
homolog to TNNI3
Homologene
FAMILY
  • troponin I family
  • CATEGORY motor/contractile , regulatory , structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • preventing actin and myosin interaction in resting muscle tissue
  • involved in the regulation of muscle contraction
  • may be playing a role in regulation of smooth muscle function
  • playing potentially a role in regulation of smooth muscle function
  • inhibitory subunit of the troponin complex in the sarcomeric thin filament of striated muscle and plays a central role in the calcium regulation of contraction and relaxation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • inhibitory subunit of troponin
  • Troponin consists of three subunits: an inhibitory subunit TNNI2, a Ca2+-binding subunit TNNC2, and TNNT2
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to actin-tropomyosin
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) AMCD2B
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS