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FLASH GENE

Symbol

TNNI2

contributors: mct/npt/pgu - updated : 28-12-2016

HGNC name	troponin I type 2 (skeletal, fast)
HGNC id	11946

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive pharynx         Nervous nerve

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum cardiac     Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	ortholog to murine Tnni2
	homolog to C.elegans W03F8.1

intraspecies	homolog to TNNI1
	homolog to TNNI3

Homologene

FAMILY

troponin I family

CATEGORY

motor/contractile , regulatory , structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton

basic FUNCTION	preventing actin and myosin interaction in resting muscle tissue
	involved in the regulation of muscle contraction
	may be playing a role in regulation of smooth muscle function
	playing potentially a role in regulation of smooth muscle function
	inhibitory subunit of the troponin complex in the sarcomeric thin filament of striated muscle and plays a central role in the calcium regulation of contraction and relaxation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	inhibitory subunit of troponin
	Troponin consists of three subunits: an inhibitory subunit TNNI2, a Ca2+-binding subunit TNNC2, and TNNT2

INTERACTION

DNA

RNA

small molecule

protein

binding to actin-tropomyosin

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

AMCD2B

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS