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FLASH GENE
Symbol TNNI2 contributors: mct/npt/pgu - updated : 28-12-2016
HGNC name troponin I type 2 (skeletal, fast)
HGNC id 11946
Corresponding disease
AMCD2B arthrogryposis multiplex congenita, distal, type IIB
Location 11p15.5      Physical location : 1.860.232 - 1.862.910
Synonym name
  • troponin I2, inhibitory subunit
  • troponin I, skeletal, fast
  • troponin I, fast-twitch skeletal muscle isoform
  • troponin I fast twitch 2
  • Synonym symbol(s) AMCD2B, DA2B, FSSV, fTnI
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    text organized in pair with TNNT3
    STRUCTURE 2.01 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence
    text structure putative regulatory element in the 5'region and a region containing MEF2, E-box, CCAC and CAGG element
    MAPPING cloned Y linked N status confirmed
    Map pter - TNNI2 - D11S922 - D11S932 - D11S1350 - cen
    Physical map
    RPLP2 5q31 ribosomal protein, large P2 TTS-2.2 11p15.5 transport-secretion protein 2.2 MGC45840 11p15.5 hypothetical protein MGC45840 CD151 11p15.5 CD151 antigen POLR2L 11p15 polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa TM4SF7 11p15.5 transmembrane 4 superfamily member 7 MGC3234 11p15.5 hypothetical protein MGC3234 AP2A2 11p15.5 adaptor-related protein complex 2, alpha 2 subunit MUC6 11p15.5 mucin 6, gastric LOC387738 11 similar to secreted gel-forming mucin LOC338731 11p15.5 hypothetical LOC338731 LOC387739 11 LOC387739 LOC387740 11 similar to Mucin 2 precursor (Intestinal mucin 2) MUC5B 11p15.5 mucin 5, subtype B, tracheobronchial TOLLIP 11p15.5 toll interacting protein STK29 11p15.5 serine/threonine kinase 29 HCCA2 11p15.5 HCCA2 protein DUSP8 11p15.5 dual specificity phosphatase 8 LOC387741 11 hypothetical gene supported by AK124823 LOC387742 11 hypothetical gene supported by AK124823 CTSD 11p15.5 cathepsin D (lysosomal aspartyl protease) LOC255701 11p15.5 similar to large subunit ribosomal protein L36a LOC390029 11 similar to A-X actin SYT8 11p15.5 synaptotagmin VIII TNNI2 11p15.5 troponin I, skeletal, fast LSP1 11p15.5 lymphocyte-specific protein 1 TNNT3 11p15.5 troponin T3, skeletal, fast MRPL23 11p15.5 mitochondrial ribosomal protein L23 LOC387743 11 LOC387743 H19 11p15.5 H19, imprinted maternally expressed untranslated mRNA IGF2 11p15.5 insulin-like growth factor 2 (somatomedin A) IGF2AS 11p15.5 insulin-like growth factor 2, antisense INS 11p15.5 insulin TH 11p15.5 tyrosine hydroxylase ASCL2 11p15.5 achaete-scute complex-like 2 (Drosophila) C11orf21 11p15.5 chromosome 11 open reading frame 21 PHEMX 11p15.5 pan-hematopoietic expression CD81 11p15.5 CD81 antigen (target of antiproliferative antibody 1) TSSC4 11p15.5 tumor suppressing subtransferable candidate 4 TRPM5 11p15.5 transient receptor potential cation channel, subfamily M, member 5 KCNQ1 11p15.5 potassium voltage-gated channel, KQT-like subfamily, member 1
    regionally located tightly linked to TNNT2 and ELF3
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 700 21.21 182 - 2008 18548613
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestivepharynx    
    Nervousnerve    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to murine Tnni2
    homolog to C.elegans W03F8.1
    intraspecies homolog to TNNI1
    homolog to TNNI3
    Homologene
    FAMILY
  • troponin I family
  • CATEGORY motor/contractile , regulatory , structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • preventing actin and myosin interaction in resting muscle tissue
  • involved in the regulation of muscle contraction
  • may be playing a role in regulation of smooth muscle function
  • playing potentially a role in regulation of smooth muscle function
  • inhibitory subunit of the troponin complex in the sarcomeric thin filament of striated muscle and plays a central role in the calcium regulation of contraction and relaxation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • inhibitory subunit of troponin
  • Troponin consists of three subunits: an inhibitory subunit TNNI2, a Ca2+-binding subunit TNNC2, and TNNT2
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to actin-tropomyosin
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) AMCD2B
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS