Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CNR2 contributors: - updated : 10-03-2006
HGNC name cannabinoid receptor 2 (macrophage)
HGNC id 2160
Location 1p36.11      Physical location : 24.200.460 - 24.239.817
Synonym symbol(s) CB2, CX5, EVI11, CB2R
DNA
TYPE functioning gene
STRUCTURE 39.00 kb     2 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
PDE4DIP 1q12 phosphodiesterase 4D interacting protein (myomegalin) LOC388776 1 similar to AG02 LOC391202 1 similar to Tissue alpha-L-fucosidase precursor (Alpha-L-fucosidase I) (Alpha-L-fucoside fucohydrolase) LOC388763 1 similar to Ankrd3-prov protein LOC391208 1 similar to mCAF1 protein LOC388764 1 similar to hypothetical protein MGC3047 MTF1 1p34-p32 metal-regulatory transcription factor 1 DKFZp434K1323 1p36.33 CXYorf1-related protein LOC388570 1 similar to hypothetical protein CNR2 1p36.11 cannabinoid receptor 2 (macrophage) LOC391210 1 similar to Olfactory receptor 2T3 FLJ23550 1q23.3 hypothetical protein FLJ23550 LOC391205 1 similar to RIKEN cDNA B230396O12 DKFZp434D177-likLOC391204 LOC391204 1 similar to plectin LOC391211 1 similar to Olfactory receptor 2G3 MGC10334 1p36.33 hypothetical protein MGC10334 LOC388777 1 similar to hypothetical protein DJ328E19.C1.1 SH120 1p36.13-q31.3 putative G-protein coupled receptor MMP23B 1p36.3 matrix metalloproteinase 23B CDC2L2 1p36.33 cell division cycle 2-like 2 CDC2L1 1p36.33 cell division cycle 2-like 1 (PITSLRE proteins) LOC391201 1 similar to hypothetical protein FLJ10709 LOC391212 1 similar to Olfactory receptor 2T5 S100A3 1q21 S100 calcium binding protein A3 LOC391203 1 similar to 14.5 kDa translational inhibitor protein (p14.5) (UK114 antigen homolog) LOC388765 1 hypothetical gene supported by BK000152 LOC391209 1 similar to ribosomal protein L36; 60S ribosomal protein L36 PNRC2 1p36.11 proline-rich nuclear receptor coactivator 2 LOC391213 1 similar to seven transmembrane helix receptor LOC388766 1 hypothetical gene supported by BC059409; NM_022834 LOC388770 1 similar to TBP-associated factor 1A isoform 1; SL1, 48kD subunit FUSIP1 1p36.11 FUS interacting protein (serine-arginine rich) 1
regionally located located in rhabdomyosarcoma (RMS) breakpoint region
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - - 1776 - 360 - Munro
- - polyA site 5000 - - - Munro
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
Lymphoid/Immunelymph node    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoietic    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunemacrophage
Skeletonosteoblast
Skeletonosteoclast
cell lineage
  • myeloid cell lines
  • cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    seven transmembrane segments (7TM) receptor, hematopoietic
    HOMOLOGY
    interspecies homolog to murine Cnr2
    Homologene
    FAMILY family 1 of G protein coupled receptor
    CATEGORY protooncogene , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • inhibiting adenylate cyclase
  • putatively involved in the initiation of cell maturation
  • playing an essential role for the maintenance of normal bone mass by osteoblastic and osteoclastic signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein upregulating nine genes involved in cytokine synthesis, regulation of transcription, cell differentiation
    cell & other
    REGULATION
    activated by 2-arachidonoylglycerol
    elevated endogenous levels of endocannabinoids
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to ostoporosis (low hip BMD)
    Variant & Polymorphism SNP increasing the risk of osteoporosis
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    osteoarticularbone 
    molecular target for the diagnosis and treatment of osteoporosis and other bone diseases (antagonists of CNR2)
    ANIMAL & CELL MODELS