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FLASH GENE
Symbol CNR2 contributors: - updated : 10-03-2006
HGNC name cannabinoid receptor 2 (macrophage)
HGNC id 2160
Location 1p36.11      Physical location : 24.200.460 - 24.239.817
Synonym symbol(s) CB2, CX5, EVI11, CB2R
DNA
TYPE functioning gene
STRUCTURE 39.00 kb     2 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
regionally located located in rhabdomyosarcoma (RMS) breakpoint region
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - - 1776 - 360 - Munro
- - polyA site 5000 - - - Munro
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
Lymphoid/Immunelymph node    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoietic    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunemacrophage
Skeletonosteoblast
Skeletonosteoclast
cell lineage
  • myeloid cell lines
  • cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    seven transmembrane segments (7TM) receptor, hematopoietic
    HOMOLOGY
    interspecies homolog to murine Cnr2
    Homologene
    FAMILY family 1 of G protein coupled receptor
    CATEGORY protooncogene , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • inhibiting adenylate cyclase
  • putatively involved in the initiation of cell maturation
  • playing an essential role for the maintenance of normal bone mass by osteoblastic and osteoclastic signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein upregulating nine genes involved in cytokine synthesis, regulation of transcription, cell differentiation
    cell & other
    REGULATION
    activated by 2-arachidonoylglycerol
    elevated endogenous levels of endocannabinoids
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to ostoporosis (low hip BMD)
    Variant & Polymorphism SNP increasing the risk of osteoporosis
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    osteoarticularbone 
    molecular target for the diagnosis and treatment of osteoporosis and other bone diseases (antagonists of CNR2)
    ANIMAL & CELL MODELS