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FLASH GENE
Symbol CNR2 contributors: mct - updated : 15-12-2021
HGNC name cannabinoid receptor 2 (macrophage)
HGNC id 2160
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional       loss of function
combined deficiency of the CNR1 and CNR2 receptors protects against age-related bone loss by osteoclast inhibition
Susceptibility
  • to ostoporosis (low hip BMD)
  • to immune thrombocytopenic purpura
  • Variant & Polymorphism SNP
  • increasing the risk of osteoporosis
  • significant overrepresentation of the RR genotype and of the R allele was observed only for the chronic form of immune thrombocytopenic purpura children
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    osteoarticularbone 
    molecular target for the diagnosis and treatment of osteoporosis and other bone diseases (antagonists of CNR2)
    metabolismlipid 
    pharmacological manipulation of CB2R may provide therapeutic possibilities to treat metabolic diseases associated with lipid dysregulation
    ANIMAL & CELL MODELS
  • extensive cardiomyocyte loss and confluent scar formation were found in Cnr2-/- mice accompanied by significantly increased apoptosis and left ventricular dysfunction when compared with Cnr2 +/+ mice