| basic FUNCTION
| involved in retinal developmental vasculogenesis  |
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could play a critical role in the differentiation or maintenance of the differentiated state of the retina |
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may be involved in a pathway that regulates neural cell differentiation and proliferation |
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a possible role in neuroectodermal cell-cell interaction |
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inducing FZD4-dependent activation of the classical Wnt pathway |
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NDP-FZD4 is a signaling system playing a central role in vascular development in the eye and ear |
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playing a crucial role in hyaloid vessel regression and in sprouting angiogenesis during retinal vascular development, especially in the development of the deep retinal capillary networks |
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forms disulfide-bonded oligomers that are associated with the extracellular matrix upon secretion from cells |
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in the retina, serves as a ligand and binds to FZD4 to activate the Wnt signaling pathway in normal angiogenesis and vascularization |
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is a mitogenic stimulus for cells in the superficial retinal vascular plexus (SRVP) |
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is required downstream of HH activation to induce retinal progenitor proliferation in the retina |
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cell autonomous function for NDP in retinal progenitor proliferation that is independent of its function in the retinal vasculature, which could explain the neural defects associated with ND |
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stimulates cell proliferation in the superficial retinal vascular plexus and is pivotal for the recruitment of mural cells |
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play a crucial role in retinal vascularization |
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cysteine-rich growth factor that is required for angiogenesis in the eye, ear, brain, and female reproductive organs |
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may play a role in the regulation of angiogenesis in the colorectal cancer tumor microenvironment |
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protected blood-brain barrier integrity and improved neurological outcome after subarachnoid hemorrhage, and the action of NDP appeared mediated by FZD4 receptor activation |
