protein
| interacting with RUNX1 in osteoblasts |
|
binding to FGFR2 promoter and interacting with RUNX2 |
|
overexpression of WDR5 in the perichondrium promotes chondrocyte differentiation by modulating the expression of TWIST1 and FGF18 |
|
regulating with MSX2 the expression of EFNA4 |
|
interaction of TWIST1 with a novel protein candidate TCF4 |
|
direct regulation of BMI1 by TWIST1, and the functional interdependence between TWIST1 and BMI1, involved in promoting EMT and the tumour-initiating capability of head and neck cancer cells |
|
SNAI1 controls ZEB1 expression at multiple levels and acts cooperatively with TWIST1 in the ZEB1 gene transcription induction |
|
TWIST1, TWIST2 are novel inhibitory binding partners of ATF4 |
|
SETD8 acts as a dual epigenetic modifier on the promoters of the TWIST1 target genes CDH1 and CDH2 via its H4K20 monomethylation activity |
|
TWIST1 binds directly to SOX9 and inhibits both SOX9-dependent gene activation and SOX9 binding to target gene enhancer DNA in chondrogenic cells |
|
is an inhibitor of SOX9, suggesting that the balance between TWIST1 and SOX9 may determine the earliest steps of chondrogenesis |
|
up-regulation of TWIST1 decreased both gene and protein expression levels of endogenous CLDN4 and the suppression was mediated by direct binding of TWIST1 to the canonical E-box in the promoter region of CLDN4 |
|
TWIST1 regulation of IFNG depends on complex formation with RUNX3 |
|
regulatory cascade containing PPARG and TWIST1 that controlled the expression of GPS2 and NCOR2 in human adipocytes |
|
TWIST1 expression did not increase the secretion of the common proangiogenic factors VEGFA and basic fibroblast growth factor but rather induced expression of the macrophage chemoattractant CCL2 |
|
interacts with the pro-neural factor SOX10 via its Twist-box domain and binds to the PHOX2B promoter to repress transcriptional activity |
|
is an important potential downstream effector, playing a key role in TFF3-modulated metastasis in gastric cancer |
|
HDAC5 promotes osteosarcoma progression by upregulation of TWIST1 expression |
|
SOX5 transactivates TWIST1 expression and plays an important role in the regulation of breast cancer progression |
|
SQSTM1 binds to TWIST1 and inhibits degradation of TWIST1 |
|
TWIST1-binding sequences associated with CHST11, LITAF, ROR2, and SPATA5 also bound the potential TWIST1 cofactor RREB1 |
|
is required for tumor initiation and maintenance in a TP53-dependent and -independent manner |
|
NOTCH1 inhibits chondrogenic differentiation of mesenchymal progenitor cells by targeting TWIST1 |
|
TWIST1 and TWIST2 were required for optimal cytokine downregulation during acute and, particularly, chronic NOD2 stimulation of human macrophages |
|
TWIST1 mediates the modulatory function of PAQR3 on epithelial-mesenchymal transition (EMT) and metastasis |
|
indirect binding of TWIST1 to the E-boxes of MAGEA4 promoter sequence and a novel regulatory role of TWIST1 in MAGEA4 upregulation |
|
ZHX1 could contribute to glioblastoma progression via the regulations of TWIST1 and SNAI2 |
|
SPZ1, a newly dscribed molecule, transactivates TWIST1 promoters, and this SPZ1-TWIST axis mediates EMT signaling and exerts significant regulatory effects on tumor oncogenesis |
|
SOX6 interact with the promoter of TWIST1, a helix-loop-helix transcription factor involved in the induction of EMT, and to modulate the expression of TWIST1 by recruiting HDAC1 to the promoter of the TWIST1 gene |
|
KAT5 mediates acetylation at lysine residues of SPZ1 at positions 369 and 374, and of TWIST1 at positions 73 and 76, which are required for SPZ1-TWIST1 complex formation and cancer cell migration |
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
|  
|  
| gain of function
|
in breast carcinoma, gastric and lung cancer with metastasis | tumoral
|  
|  
| --over
|  
|
in gliomas and promotes invasion | tumoral
|  
|  
| --low
|  
|
by hypermethylation is observed frequently in colorectal tumors | tumoral
|  
|  
| --over
|  
|
associated with unfavorable outcomes in patients with colorectal cancer | tumoral
| somatic mutation
|  
|  
|  
|
in giant cell tumor of bone, leading to inappropriate TWIST1 downregulation of RUNX2, arrested osteoblastic differentiation, and the maintenance of an immature and neoplastic phenotype ( | constitutional
|  
|  
| --other
|  
|
epithelial expression of TWIST1 were disturbed in those placentas with chromosomal aberrations | constitutional
|  
|  
| --over
|  
|
hypomethylation is associated with overexpression of PLS3, GATA6, and TWIST1 in the Sezary Syndrome | |