SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,cytosolic
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
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| intracellular,cytoplasm,cytoskeleton,intermed filament
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| intracellular,nucleus,nucleoplasm
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| intracellular,nucleus,chromatin/chromosome,kinetochore
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| text
| cytoplasmic retention also required for PEA15 to impair kinase activity of RPS6KA3 |
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localizes at the kinetochores under spindle checkpoint conditions, and during mitosis, associated with the centrosomes, the spindle and at the mid-body  |
| basic FUNCTION
| involved in the activation of glycogen synthesis and playing important role in learning and memory |
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required for epidermal growth factor activated phosphorylation of histone H3, which may cause chromatin remodeling and facilitate gene transcription |
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involved in cell proliferation and differentiation but not in vivo in the phosphorylation of RPS6 |
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mediating protein synthesis initiation and elongation induced by hormones or growth factors |
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noteworthy required for growth factor stimulated transcription of FOS |
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maybe playing an essential regulatory role in protein synthesis during cell proliferation |
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required for osteoblast differentiation and function through its ability to phosphorylate specific transcription factors |
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critical upstream signaling element in the activation of PLD1 to produce the lipids required for exocytosis |
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pivotal factor linking the stress response to survival and proliferation |
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is a critical mediator of inhibitory cross-talk between receptor tyrosine kinases and 5-hydroxytryptamine 2A receptors (5-HT2AR) by phosphorylating 5-HT2AR |
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novel role for RPS6KA3 in cognitive processes , suggesting the critical implication of an intriguing brain structure in place aversion learning |
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is a key regulator of integrin activity, suggesting a novel mechanism by which it may promote cell migration and cancer metastasis |
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promotes G2/M transition in mammalian cells through activating phosphorylation of CDC25A and CDC25B |
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plays a key role in cell proliferation and transformation induced by tumor promoters such as epidermal growth factor (EGF) in human skin cells |
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plays an important role in stress-tolerance and cell survival, resulting in cell proliferation and cancer development |
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is a modulator of craniofacial development |
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is a critical regulator of cementoblast function |
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is a nonredundant regulator of cementum homeostasis, alveolar bone maintenance, and periodontal health, with all these features being independent of RPS6KA3 function in systemic bone formation |
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downstream kinase of the mitogen-activated protein kinase (MAPK) pathway, which is important in regulating survival, transcription, growth and proliferation |
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affects mitotic progression by regulating the distribution, basal level and the stability of mitotic spindles |
