| 1 | PDPK1, RPS6KA3
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| PDK1 promotes the inflammatory progress of fibroblast-like synoviocytes by phosphorylating RSK2.
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| Sun C, Sun Y, Jiang D, Bao G, Zhu X, Xu D, Wang Y, Cui Z.
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| Cell Immunol 315:27-33. doi: 10.1016/j.cellimm.2016.10.007. Epub 2016 Nov 1.
2017
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| 2 | RPS6KA3
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| The p90 ribosomal S6 kinase 2 specifically affects mitotic progression by regulating the basal level, distribution and stability of mitotic spindles.
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| Park YY, Nam HJ, Do M, Lee JH.
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| Exp Mol Med 48:e250. doi: 10.1038/emm.2016.61.
2016
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| 3 | CLS, RPS6KA3
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| Concomitant partial exon skipping by a unique missense mutation of RPS6KA3 causes Coffin-Lowry syndrome.
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| Labonne JD, Chung MJ, Jones JR, Anand P, Wenzel W, Iacoboni D, Layman LC, Kim HG.
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| Gene 575(1):42-7. doi: 10.1016/j.gene.2015.08.032. Epub 2015 Aug 20.
2016
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| 4 | CLS, RPS6KA3
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| Rsk2, the Kinase Mutated in Coffin-Lowry Syndrome, Controls Cementum Formation.
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| Koehne T, Jeschke A, Petermann F, Seitz S, Neven M, Peters S, Luther J, Schweizer M, Schinke T, Kahl-Nieke B, Amling M, David JP.
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| J Dent Res 95(7):752-60. doi: 10.1177/0022034516634329. Epub 2016 Feb 29.
2016
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| 5 | FGFR2, RPS6KA3
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| Interactions between FGFR2 and RSK2-implications for breast cancer prognosis.
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| Czaplinska D, Mieczkowski K, Supernat A, Skladanowski AC, Kordek R, Biernat W, Zaczek AJ, Romanska HM, Sadej R.
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| Tumour Biol 37(10):13721-13731. Epub 2016 Jul 30.
2016
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| 6 | RPS6KA3, SLC9A3
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| Regulation of NHE3 by lysophosphatidic acid is mediated by phosphorylation of NHE3 by RSK2.
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| No YR, He P, Yoo BK, Yun CC.
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| Am J Physiol Cell Physiol 309(1):C14-21. doi: 10.1152/ajpcell.00067.2015. Epub 2015 Apr 8.
2015
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| 7 | RPS6KA3
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| RSK2 is a modulator of craniofacial development.
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| Laugel-Haushalter V, Paschaki M, Marangoni P, Pilgram C, Langer A, Kuntz T, Demassue J, Morkmued S, Choquet P, Constantinesco A, Bornert F, Schmittbuhl M, Pannetier S, Viriot L, Hanauer A, Dollé P, Bloch-Zupan A.
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| PLoS One 9(1):e84343. doi: 10.1371/journal.pone.0084343. eCollection 2014.
2014
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| 8 | FGFR1, RPS6KA3
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| RSK2 regulates endocytosis of FGF receptor 1 by phosphorylation on serine 789.
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| Nadratowska-Wesolowska B, Haugsten EM, Zakrzewska M, Jakimowicz P, Zhen Y, Pajdzik D, Wesche J, Wiedlocha A.
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| Oncogene 33(40):4823-36. doi: 10.1038/onc.2013.425. Epub 2013 Oct 21.
2014
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| 9 | CDC25A, CDC25B, RPS6KA3
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| RSK promotes G2/M transition through activating phosphorylation of Cdc25A and Cdc25B.
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| Wu CF, Liu S, Lee YC, Wang R, Sun S, Yin F, Bornmann WG, Yu-Lee LY, Gallick GE, Zhang W, Lin SH, Kuang J.
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| Oncogene ncogene. 2013 May 27. doi: 10.1038/onc.2013.182. [Epub ahead of print]
2013
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| 10 | RPS6KA3
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| RSK2-induced stress tolerance enhances cell survival signals mediated by inhibition of GSK3β activity.
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| Lee CJ, Lee MH, Lee JY, Song JH, Lee HS, Cho YY.
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| Biochem Biophys Res Commun 440(1):112-8. doi: 10.1016/j.bbrc.2013.09.042. Epub 2013 Sep 17.
2013
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| 11 | RPS6KA3
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| RSK2 protein suppresses integrin activation and fibronectin matrix assembly and promotes cell migration.
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| Gawecka JE, Young-Robbins SS, Sulzmaier FJ, Caliva MJ, Heikkilä MM, Matter ML, Ramos JW.
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| J Biol Chem 287(52):43424-37. doi: 10.1074/jbc.M112.423046. Epub 2012 Nov 1.
2012
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| 12 | RPS6KA3
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| RSK2 signaling in brain habenula contributes to place aversion learning.
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| Darcq E, Koebel P, Del Boca C, Pannetier S, Kirstetter AS, Garnier JM, Hanauer A, Befort K, Kieffer BL.
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| Learn Mem 18(9):574-8. doi: 10.1101/lm.2221011. Print 2011 Sep.
2011
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| 13 | RPS6KA3
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| p90 Ribosomal S6 kinase 2, a novel GPCR kinase, is required for growth factor-mediated attenuation of GPCR signaling.
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| Strachan RT, Allen JA, Sheffler DJ, Roth BL.
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| Biochemistry 49(12):2657-71.PMID: 20136148 2010
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| 14 | CENPE, RPS6KA3
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| RSK2 is a kinetochore-associated protein that participates in the spindle assembly checkpoint.
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| Vigneron S, Brioudes E, Burgess A, Labbé JC, Lorca T, Castro A.
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| Oncogene 29(24):3566-74. Epub 2010 Apr 12. 2010
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| 15 | CLS, RPS6KA3
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| Coffin-Lowry syndrome.
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| Pereira PM, Schneider A, Pannetier S, Heron D, Hanauer A.
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| Eur J Hum Genet 18(6):627-33. Epub 2009 Nov 4. Review.PMID: 19888300 2010
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| 16 | FGFR3, RPS6KA3
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| Fibroblast growth factor receptor 3 associates with and tyrosine phosphorylates p90 RSK2, leading to RSK2 activation that mediates hematopoietic transformation.
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| Kang S, Elf S, Dong S, Hitosugi T, Lythgoe K, Guo A, Ruan H, Lonial S, Khoury HJ, Williams IR, Lee BH, Roesel JL, Karsenty G, Hanauer A, Taunton J, Boggon TJ, Gu TL, Chen J.
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| Mol Cell Biol 29(8):2105-17. Epub 2009 Feb 17.
2009
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| 17 | RPS6KA3, PLD1, SCRIB
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| The Coffin-Lowry syndrome-associated protein RSK2 is implicated in calcium-regulated exocytosis through the regulation of PLD1.
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| Zeniou-Meyer M, Liu Y, Bgl A, Olanish M, Hanauer A, Becherer U, Rettig J, Bader MF, Vitale N.
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| Proc Natl Acad Sci U S A 105(24):8434-9. Epub 2008 Jun 11. 2008
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| 18 | RPS6KA3
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| Epidermal growth factor stimulates RSK2 activation through activation of the MEK/ERK pathway and src-dependent tyrosine phosphorylation of RSK2 at Tyr-529.
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| Kang S, Dong S, Guo A, Ruan H, Lonial S, Khoury HJ, Gu TL, Chen J.
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| J Biol Chem 283(8):4652-7. Epub 2007 Dec 21. 2008
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| 19 | RPS6KA3, TIA1
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| Codependent functions of RSK2 and the apoptosis-promoting factor TIA-1 in stress granule assembly and cell survival.
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| Eisinger-Mathason TS, Andrade J, Groehler AL, Clark DE, Muratore-Schroeder TL, Pasic L, Smith JA, Shabanowitz J, Hunt DF, Macara IG, Lannigan DA.
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| Mol Cell 31(5):722-36.
2008
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| 20 | RPS6KA3, CLS
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| The first large duplication of the RSK2 gene identified in a Coffin-Lowry syndrome patient.
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| Marques Pereira P, Heron D, Hanauer A.
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| Hum Genet 122(5):541-3. Epub 2007 Aug 24. 2007
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| 21 | NFATC4, RPS6KA3
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| RSK2 mediates muscle cell differentiation through regulation of NFAT3.
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| Cho YY, Yao K, Bode AM, Bergen HR 3rd, Madden BJ, Oh SM, Ermakova S, Kang BS, Choi HS, Shim JH, Dong Z.
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| J Biol Chem 282(11):8380-92. Epub 2007 Jan 9.
2007
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| 22 | ACSL4, AFF2, AGTR2, ARHGEF6, ARX, ATRX, DLG3, ESMR, FTSJ1, GDI1, IL1RAPL1, KDM5C, MECP2, MRX68, MRX89, MRX90, MRXS31, NLGN3, NLGN4X, OPHN1, PQBP1, RPS6KA3, RTTM, SLC16A2, SLC6A8, SYN1, TSPAN7, ZNF41
|
| X linked mental retardation: a clinical guide.
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| Raymond FL.
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| J Med Genet 43(3):193-200. Epub 2005 Aug 23. 2006
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| 23 | CLS, RPS6KA3
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| A novel RSK2 (RPS6KA3) gene mutation associated with abnormal brain MRI findings in a family with Coffin-Lowry syndrome.
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| Wang Y, Martinez JE, Wilson GL, He XY, Tuck-Muller CM, Maertens P, Wertelecki W, Chen TJ.
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| Am J Med Genet A 140(12):1274-9. 2006
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| 24 | RPS6KA3, CLS
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| Identification of novel mutations in the RSK2 gene (RPS6KA3) in patients with Coffin-Lowry syndrome.
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| Delaunoy JP, Dubos A, Marques Pereira P, Hanauer A.
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| Clin Genet 70(2):161-6. 2006
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| 25 | MRX19, CLS, RPS6KA3
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| Mutations in the RSK2(RPS6KA3) gene cause Coffin-Lowry syndrome and nonsyndromic X-linked mental retardation.
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| Field M, Tarpey P, Boyle J, Edkins S, Goodship J, Luo Y, Moon J, Teague J, Stratton MR, Futreal PA, Wooster R, Raymond FL, Turner G.
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| Clin Genet 70(6):509-15. 2006
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| 26 | RPS6KA3, CLS
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| RSK2 gene mutations in Coffin-Lowry syndrome with drop episodes.
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| Nakamura M, Yamagata T, Mori M, Momoi MY.
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| Brain Dev 27(2):114-7. 2005
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| 27 | ATRX, CREBBP, DNMT3B, MECP2, RPS6KA3
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| Syndromes of disordered chromatin remodeling.
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| Ausio J, Levin DB, De Amorim GV, Bakker S, Macleod PM.
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| Clin Genet 64(2):83-95. 2003
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| 28 | RPS6KA3, PEA15
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| RSK2 activity is regulated by its interaction with PEA-15.
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| Vaidyanathan H, Ramos JW.
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| J Biol Chem 278(34):32367-72. Epub 2003 Jun 9. 2003
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| 29 | CLS, RPS6KA3
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| X-linked Coffin-Lowry syndrome (CLS, MIM 303600, RPS6KA3 gene, protein product known under various names: pp90(rsk2), RSK2, ISPK, MAPKAP1).
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| Jacquot S, Zeniou M, Touraine R, Hanauer A.
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| Eur J Hum Genet 10(1):2-5. 2002
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| 30 | CLS, RPS6KA3
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| Unusual splice-site mutations in the RSK2 gene and suggestion of genetic heterogeneity in Coffin-Lowry syndrome.
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| Zeniou M, Pannetier S, Fryns JP, Hanauer A.
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| Am J Hum Genet 70(6):1421-33. 2002
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| 31 | RPS6KA1, RPS6KA2, RPS6KA3
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| Expression analysis of RSK gene family members: the RSK2 gene, mutated in Coffin-Lowry syndrome, is prominently expressed in brain structures essential for cognitive function and learning.
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| Zeniou M, Ding T, Trivier E, Hanauer A.
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| Hum Mol Genet 11(23):2929-40. 2002
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| 32 | RPS6KA3
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| Cognitive impairment in Coffin-Lowry syndrome correlates with reduced RSK2 activation.
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| Harum KH, Alemi L, Johnston MV.
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| Neurology 56(2):207-14. 2001
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| 33 | CLS, RPS6KA3
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| Mutations in the X-linked RSK2 gene (RPS6KA3) in patients with Coffin-Lowry syndrome.
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| Delaunoy J, Abidi F, Zeniou M, Jacquot S, Merienne K, Pannetier S, Schmitt M, Schwartz C, Hanauer A.
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| Hum Mutat 17(2):103-16. 2001
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| 34 | PDPK1, RPS6KA3
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| A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1.
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| Frodin M, Jensen CJ, Merienne K, Gammeltoft S.
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| EMBO J 19(12):2924-34. 2000
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| 35 | FOS, RPS6KA3
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| Ribosomal subunit kinase-2 is required for growth factor-stimulated transcription of the c-Fos gene.
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| Bruning JC, Gillette JA, Zhao Y, Bjorbaeck C, Kotzka J, Knebel B, Avci H, Hanstein B, Lingohr P, Moller DE, Krone W, Kahn CR, Muller-Wieland D.
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| Proc Natl Acad Sci U S A 97(6):2462-7. 2000
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| 36 | CLS, RPS6KA3
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| Novel mutations in Rsk-2, the gene for Coffin-Lowry syndrome.
|
| Abidi F, et al.
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| Eur J Hum Genet 7(1):20-6. 1999
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| 37 | MRX19, RPS6KA3
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| A missense mutation in RPS6KA3 (RSK2) responsible for non-specific mental retardation.
|
| Merienne K, et al.
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| Nat Genet 22(1):13-4. No abstract available 1999
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| 38 | RPS6KA3
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| Requirement of Rsk-2 for epidermal growth factor-activated phosphorylation of histone H3.
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| Sassone-Corsi P, et al.
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| Science 285(5429):886-91 1999
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| 39 | CLS, RPS6KA3
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| Coffin-Lowry syndrome: current status.
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| Jacquot S, Merienne K, Trivier E, Zeniou M, Pannetier S, Hanauer A.
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| Am J Med Genet 85(3):214-5. No abstract available. 1999
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| 40 | OPHN1, FGD1, FMR1, GDI1, PAK3, RPS6KA3, MRX1
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| Breakthroughs in molecular and cellular mechanisms underlying X-linked mental retardation.
|
| Chelly J.
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| Hum Mol Genet 8(10):1833-8. Review. 1999
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| 41 | CLS, RPS6KA3
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| Germline mosaicism in Coffin-Lowry syndrome.
|
| Jacquot S, et al.
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| Eur J Hum Genet 6 : 578-582. 1998
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| 42 | CLS, RPS6KA3
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| Mutation analysis of the RSK2 gene in Coffin-Lowry patients : extensive allelic heterogeneity and a high rate of de novo mutations.
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| Jacquot S, Merienne K, De Cesare D, Pannetier S, Mandel JL, Sassone-Corsi P, Hanauer A.
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| Am J Hum Genet 63 : 1631-1640. 1998
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| 43 | CLS, RPS6KA3
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| Mutations in the kinase Rsk-2 associated with Coffin-Lowry syndrome.
|
| Trivier E, et al.
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| Nature 384 : 567-570. 1996
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| 44 | RPS6KA3
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| Construction of a YAC contig and an STS map spanning 3.6 megabase pairs in Xp22.1. (abstract).
|
| Trump D, et al.
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| Cytogenet Cell Genet 71 : 337. 1995
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| 45 | RPS6KA3
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| Cloning of a human insulin-stimulated protein kinase (ISPK-1) gene and analysis of coding regions and mRNA levels of the ISPK-1 and the protein phosphatase-1 genes in muscle from NIDDM patients.
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| Bjrbaek C, et al.
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| Diabetes 44 : 90-97. 1995
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| 46 | RPS6KA1, RPS6KA2, RPS6KA3
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| Signal transduction via the MAP kinases : proceed at your own RSK.
|
| Blenis J.
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| Proc Natl Acad Sci U S A 90 : 5889-5892. 1993
|