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FLASH GENE
Symbol PDK4 contributors: mct/npt - updated : 21-12-2019
HGNC name pyruvate dehydrogenase kinase, isoenzyme 4
HGNC id 8812
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • histidine-kinase domain
    • HOMOLOGY
    interspecies homolog to murine Pdk4
    Homologene
    FAMILY
  • pdk/bckdk protein kinase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • pyruvate dehydrogenase kinase 4, regulating mitochondrial PDH activity
  • with PDK3 and PDK2 are primary PPARbeta/delta target genes underlining the importance of the receptor in the control of metabolism (Degenhardt 2007)
  • regulation of glycolysis by PDK2, PDK4 functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with FOXO1 to regulate energetic metabolism
  • ZBTB2 may increase cell proliferation by reprogramming glucose metabolic pathways to favor glycolysis by upregulating PDK4 expression via repression of RELA/p65 expression
  • PDK2 and PDK4, key regulatory enzymes in glucose metabolism, mediate glycolytic metabolic shift in the DRG leading to painful diabetic neuropathy
    • cell & other
    REGULATION
    induced by CEBPB (induced PDK4 gene expression and decreased PDC activity)
    Other regulated by retinoic acids (RA) as well as Trichostatin A (TSA), an inhibitor of histone deacetylase (HDAC)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in tissues other than the liver is clearly important during starvation for regulation of PDC (pyruvate dehydrogenase complex) activity and glucose homoeostasis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS