| 1 | PDK2, PDK4
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| Pyruvate Dehydrogenase Kinase-mediated Glycolytic Metabolic Shift in the Dorsal Root Ganglion Drives Painful Diabetic Neuropathy.
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| Rahman MH, Jha MK, Kim JH, Nam Y, Lee MG, Go Y, Harris RA, Park DH, Kook H, Lee IK, Suk K.
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| J Biol Chem 291(11):6011-25. doi: 10.1074/jbc.M115.699215. Epub 2016 Jan 14.
2016
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| 2 | PDK4, RELA, ZBTB2
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| ZBTB2 increases PDK4 expression by transcriptional repression of RelA/p65.
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| Kim MY, Koh DI, Choi WI, Jeon BN, Jeong DY, Kim KS, Kim K, Kim SH, Hur MW.
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| Nucleic Acids Res. Feb 18;43(3):1609-25. doi: 10.1093/nar/gkv026. Epub 2015 Jan 21. 2015
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| 3 | PDK2, PDK4
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| Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells.
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| Takubo K, Nagamatsu G, Kobayashi CI, Nakamura-Ishizu A, Kobayashi H, Ikeda E, Goda N, Rahimi Y, Johnson RS, Soga T, Hirao A, Suematsu M, Suda T.
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| Cell Stem Cell 12(1):49-61. doi: 10.1016/j.stem.2012.10.011.
2013
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| 4 | CEBPB, PDK4
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| Regulation of pyruvate dehydrogenase kinase 4 (PDK4) by CCAAT/enhancer-binding protein beta (C/EBPbeta).
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| Attia RR, Sharma P, Janssen RC, Friedman JE, Deng X, Lee JS, Elam MB, Cook GA, Park EA.
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| J Biol Chem 286(27):23799-807. doi: 10.1074/jbc.M111.246389. Epub 2011 May 17.
2011
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| 5 | PDK4
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| Elevated free fatty acids attenuate the insulin-induced suppression of PDK4 gene expression in human skeletal muscle: potential role of intramuscular long-chain acyl-coenzyme A.
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| Tsintzas K, Chokkalingam K, Jewell K, Norton L, Macdonald IA, Constantin-Teodosiu D.
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| J Clin Endocrinol Metab 92(10):3967-72. Epub 2007 Jul 24. 2007
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| 6 | PDK2, PDK3, PDK4
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| Three members of the human pyruvate dehydrogenase kinase gene family are direct targets of the peroxisome proliferator-activated receptor beta/delta.
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| Degenhardt T, Saramäki A, Malinen M, Rieck M, Väisänen S, Huotari A, Herzig KH, Müller R, Carlberg C.
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| J Mol Biol 372(2):341-55. Epub 2007 Jul 19.PMID: 17669420 2007
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| 7 | PDK4
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| Retinoic acids and trichostatin A (TSA), a histone deacetylase inhibitor, induce human pyruvate dehydrogenase kinase 4 (PDK4) gene expression.
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| Kwon HS, Huang B, Ho Jeoung N, Wu P, Steussy CN, Harris RA.
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| Biochim Biophys Acta 1759(3-4):141-51. Epub 2006 Apr 27. 2006
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| 8 | PDK4
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| Role of pyruvate dehydrogenase kinase isoenzyme 4 (PDHK4) in glucose homoeostasis during starvation.
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| Jeoung NH, Wu P, Joshi MA, Jaskiewicz J, Bock CB, Depaoli-Roach AA, Harris RA.
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| Biochem J 397(3):417-25. 2006
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| 9 | FOXO1,PDK4
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| Forkhead transcription factor FOXO1 (FKHR)-dependent induction of PDK4 gene expression in skeletal muscle during energy deprivation.
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| Furuyama T, Kitayama K, Yamashita H, Mori N.
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| Biochem J 375(Pt 2):365-71. 2003
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| 10 | PDK4
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| Cloning and characterization of PDK4 on 7q21.3 encoding a fourth pyruvate dehydrogenase kinase isoenzyme in human.
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| Rowles J, et al.
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| J Biol Chem 271 : 22376-22382. 1996
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