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FLASH GENE

Symbol

G6PD

contributors: mct - updated : 05-05-2020

HGNC name	glucose-6-phosphate dehydrogenase
HGNC id	4057

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

G6PDD

related resource

Favismresearchpapers

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   is a poor prognostic factor in bladder cancer, and the levels of G6PD expression increase with increasing tumor stage constitutional       loss of function significant age-dependent decrease in G6PD activity constitutional       gain of function restores redox balance in endothelial cells exposed to high glucose, which is a potentially important therapeutic target to protect ECs from the deleterious effects of high glucose constitutional       gain of function up-regulation of G6PD in pancreatic beta-cells would induce beta-cell dysregulation through ROS accumulation in the development of type 2 diabetes

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	G6PD may be a novel predictive prognostic marker for lung adenocarcinoma
Therapy target
	System Type Disorder Pubmed immunology infectious   regulation of macrophages via modulation of G6PDH activity appears to provide a novel window for those seeking to develop alternative therapies for the treatment of leishmaniasis cancer urinary   6-aminonicotinamide (6-AN), a competitive G6PD inhibitor, may be a potential therapy for bladder cancer, particularly in cases with high G6PD expression neurology acquired   G6PD may be considered as potential therapeutic target for treatment of ischemic brain injury cancer digestive colon PAK4 and/or G6PD blockage might be a potential therapeutic strategy for colon cancer

ANIMAL & CELL MODELS

G6pd-deficient mice had smaller islets and impaired glucose tolerance compared with control mice, which suggests that G6pd deficiency per se leads to beta-cell dysfunction and death