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FLASH GENE
Symbol UBL4A contributors: mct - updated : 30-12-2015
HGNC name ubiquitin-like 4A
HGNC id 12505
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal region of homology with ubiquitin
  • an ubiquitin-like domain , and UBL domains from UBL4A and BAG6 directly compete for binding to SGTA at the same site
  • a region of homology with the C terminal hormonogenic site of tyroglobulin in the central part of its (UBL4) C terminal region
  • HOMOLOGY
    interspecies homolog to C.elegans r13f6.1
    intraspecies homolog to G6PD/ubiquitin related sequence
    Homologene
    FAMILY
  • ubiquitin family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • GET4 and UBL4A are found mainly in cytoplasm
  • UBL4A and GET4 translocate to the nucleus upon DNA damage and appear to play redundant roles in cell killing, as depletion of either one has no effect but co-depletion leads to resistance
  • basic FUNCTION
  • specific role in vital functions of the cell
  • instead of targeting UBL4A for degradation, polyubiquitination is associated with irreversible proteolytic processing and inactivation of BAG6
  • converts isoform TC45 of PTPN2, a nonspecific phosphatase, into a STAT3-specific phosphatase by bridging an association between TC45 and STAT3
  • role for GET4/UBL4A in recycling ASNA1 from the ER membrane at the end of the targeting reaction
  • is required for insulin-induced AKT1 plasma membrane translocation through promotion of Arp2/3-dependent actin branching
  • CELLULAR PROCESS cell cycle
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterotrimeric BAG6 complex, which also includes UBL4A and transmembrane domain recognition complex 35 (GET4)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SGTA can bind either BAG6, or UBL4A, but not both at the same time
  • ERAD E3 AMFR can ubiquitinate not only ERAD substrates, but also the machinery protein UBL4A, a key component of the BAG6 chaperone complex
  • USP13 is a AMFR-associated DUB that eliminates ubiquitin conjugates from UBL4A to maintain the functionality of BAG6
  • UBL4A promotes STAT3 dephosphorylation via mediating the interaction between TC45 (the nuclear isoform of PTPN2) and STAT3 specifically
  • tight association of BAG6 and UBL4a resulted in modulation of UBL4a protein stability in cells
  • directly interacts with Arp2/3 to accelerate actin branching and networking
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS