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FLASH GENE

Symbol

UBL4A

contributors: mct - updated : 30-12-2015

HGNC name	ubiquitin-like 4A
HGNC id	12505

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_014235 4 - 2395 NP_055050 17 157 - 2007 16872915

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system testis       Mus musculus

cells

System Cell Pubmed Species Stage Rna symbol Reproductive sperm cell Mus musculus

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N terminal region of homology with ubiquitin
	an ubiquitin-like domain , and UBL domains from UBL4A and BAG6 directly compete for binding to SGTA at the same site
	a region of homology with the C terminal hormonogenic site of tyroglobulin in the central part of its (UBL4) C terminal region

HOMOLOGY

interspecies

homolog to C.elegans r13f6.1

intraspecies

homolog to G6PD/ubiquitin related sequence

Homologene

FAMILY

ubiquitin family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus
text	GET4 and UBL4A are found mainly in cytoplasm
	UBL4A and GET4 translocate to the nucleus upon DNA damage and appear to play redundant roles in cell killing, as depletion of either one has no effect but co-depletion leads to resistance

basic FUNCTION	specific role in vital functions of the cell
	instead of targeting UBL4A for degradation, polyubiquitination is associated with irreversible proteolytic processing and inactivation of BAG6
	converts isoform TC45 of PTPN2, a nonspecific phosphatase, into a STAT3-specific phosphatase by bridging an association between TC45 and STAT3
	role for GET4/UBL4A in recycling ASNA1 from the ER membrane at the end of the targeting reaction
	is required for insulin-induced AKT1 plasma membrane translocation through promotion of Arp2/3-dependent actin branching

CELLULAR PROCESS	cell cycle

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

heterotrimeric BAG6 complex, which also includes UBL4A and transmembrane domain recognition complex 35 (GET4)

INTERACTION

DNA

RNA

small molecule

protein	SGTA can bind either BAG6, or UBL4A, but not both at the same time
	ERAD E3 AMFR can ubiquitinate not only ERAD substrates, but also the machinery protein UBL4A, a key component of the BAG6 chaperone complex
	USP13 is a AMFR-associated DUB that eliminates ubiquitin conjugates from UBL4A to maintain the functionality of BAG6
	UBL4A promotes STAT3 dephosphorylation via mediating the interaction between TC45 (the nuclear isoform of PTPN2) and STAT3 specifically
	tight association of BAG6 and UBL4a resulted in modulation of UBL4a protein stability in cells
	directly interacts with Arp2/3 to accelerate actin branching and networking

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS