Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

Home Page

FLASH GENE

Symbol

SLC6A8

contributors: mct/pgu - updated : 13-06-2018

HGNC name	solute carrier family 6 (neurotransmitter transporter, creatine), member 8
HGNC id	11055

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

CRTRD

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   in astrocytes around the blood-brain barrier limits the brain capacity to import creatine from the periphery, and suggests that the CNS has to rely mainly on endogenous creatine synthesis through GATM/GAMT constitutional     --low   depletion of intracellular creatine by ablation of the creatine transporter SLC6A8 altered macrophage-mediated immune responses constitutional     --low   in dopaminergic neurons causes hyperactivity while sparing motor function

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     potential of creatine supplementation to improve T cell-based cancer immunotherapies cancer lung   expected to become a molecular target for NSCLC treatment

ANIMAL & CELL MODELS