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FLASH GENE

Symbol

BTK

contributors: mct/pgu - updated : 08-06-2017

HGNC name	Bruton agammaglobulinemia tyrosine kinase
HGNC id	1133

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

AGMX1 , IGHD3

related resource

Bruton Agammaglobulinemia - BTK base

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in chronic lymphocytic leukemia

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	represents a useful marker to identify B cell non-Hodgkin lymphomas
Therapy target
	System Type Disorder Pubmed cancer hemopathy   promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765 cardiovascular atheroma   could be a potent therapeutic target in ischaemic stroke cancer hemopathy   is a therapeutic target in acute myeloid leukemia

ANIMAL & CELL MODELS