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| In neurons from Fmr1 KO mice mRNAs were deficient in glutamatergic signaling-induced dendritic localization and single mRNA particle dynamics in live neurons revealed diminished kinesis | |
Mouse KO brain showed reduced kinesin-associated mRNAs |
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Fmrp-null mice show reduced adult hippocampal neurogenesis  |
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Fmr1-/- mice showed elevated response thresholds to both click and tone stimuli |
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dysregulation of Fmrp-Grm5 signaling pathway, accompanied with a downregulation of Gabrb3 expression, may contribute to the 'autistic-like' features observed in En2 mice |
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Fmr1 KO mice have decreased proinflammatory cytokine hippocampal mRNA expression, specifically interleukin (Il6 and tumor necrosis factor (Tnf), compared with wild-type mice |